Cellular RNA helicases and HIV-1: insights from genome-wide, proteomic, and molecular studies.

Chia Yen Chen, Xiang Liu, Kathleen Boris-Lawrie, Amit Sharma, Kuan Teh Jeang

Research output: Contribution to journalReview article

13 Scopus citations

Abstract

RNA helicases are ubiquitous in plants and animals and function in many cellular processes. Retroviruses, such as human immunodeficiency virus (HIV-1), encode no RNA helicases in their genomes and utilize host cellular RNA helicases at various stages of their life cycle. Here, we briefly summarize the roles RNA helicases play in HIV-1 replication that have been identified recently, in part, through genome-wide screenings, proteomics, and molecular studies. Some of these helicases augment virus propagation while others apparently participate in antiviral defenses against viral replication. Published by Elsevier B.V.

Original languageEnglish (US)
Pages (from-to)357-365
Number of pages9
JournalUnknown Journal
Volume171
Issue number2
DOIs
StatePublished - Feb 2013

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