Cells for tissue engineering of cardiac valves

Soumen Jana, Robert T. Tranquillo, Amir Lerman

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Heart valve tissue engineering is a promising alternative to prostheses for the replacement of diseased or damaged heart valves, because tissue-engineered valves have the ability to remodel, regenerate and grow. To engineer heart valves, cells are harvested, seeded onto or into a three-dimensional (3D) matrix platform to generate a tissue-engineered construct in vitro, and then implanted into a patient's body. Successful engineering of heart valves requires a thorough understanding of the different types of cells that can be used to obtain the essential phenotypes that are expressed in native heart valves. This article reviews different cell types that have been used in heart valve engineering, cell sources for harvesting, phenotypic expression in constructs and suitability in heart valve tissue engineering. Natural and synthetic biomaterials that have been applied as scaffold systems or cell-delivery platforms are discussed with each cell type.

Original languageEnglish (US)
Pages (from-to)804-824
Number of pages21
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2016

Fingerprint

Cell Engineering
Heart Valves
Tissue Engineering
Tissue engineering
Cell engineering
Tissue
Biocompatible Materials
Prosthetics
Biomaterials
Scaffolds
Prostheses and Implants
Phenotype
Engineers

Keywords

  • endothelial cell
  • fibroblast
  • heart valve
  • interstitial cell
  • myofibroblast
  • stem cell
  • tissue engineering

Cite this

Cells for tissue engineering of cardiac valves. / Jana, Soumen; Tranquillo, Robert T.; Lerman, Amir.

In: Journal of Tissue Engineering and Regenerative Medicine, Vol. 10, No. 10, 01.10.2016, p. 804-824.

Research output: Contribution to journalReview article

@article{8d50172adc444bd2aba48cc41f864be5,
title = "Cells for tissue engineering of cardiac valves",
abstract = "Heart valve tissue engineering is a promising alternative to prostheses for the replacement of diseased or damaged heart valves, because tissue-engineered valves have the ability to remodel, regenerate and grow. To engineer heart valves, cells are harvested, seeded onto or into a three-dimensional (3D) matrix platform to generate a tissue-engineered construct in vitro, and then implanted into a patient's body. Successful engineering of heart valves requires a thorough understanding of the different types of cells that can be used to obtain the essential phenotypes that are expressed in native heart valves. This article reviews different cell types that have been used in heart valve engineering, cell sources for harvesting, phenotypic expression in constructs and suitability in heart valve tissue engineering. Natural and synthetic biomaterials that have been applied as scaffold systems or cell-delivery platforms are discussed with each cell type.",
keywords = "endothelial cell, fibroblast, heart valve, interstitial cell, myofibroblast, stem cell, tissue engineering",
author = "Soumen Jana and Tranquillo, {Robert T.} and Amir Lerman",
year = "2016",
month = "10",
day = "1",
doi = "10.1002/term.2010",
language = "English (US)",
volume = "10",
pages = "804--824",
journal = "Journal of Tissue Engineering and Regenerative Medicine",
issn = "1932-6254",
publisher = "John Wiley and Sons Ltd",
number = "10",

}

TY - JOUR

T1 - Cells for tissue engineering of cardiac valves

AU - Jana, Soumen

AU - Tranquillo, Robert T.

AU - Lerman, Amir

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Heart valve tissue engineering is a promising alternative to prostheses for the replacement of diseased or damaged heart valves, because tissue-engineered valves have the ability to remodel, regenerate and grow. To engineer heart valves, cells are harvested, seeded onto or into a three-dimensional (3D) matrix platform to generate a tissue-engineered construct in vitro, and then implanted into a patient's body. Successful engineering of heart valves requires a thorough understanding of the different types of cells that can be used to obtain the essential phenotypes that are expressed in native heart valves. This article reviews different cell types that have been used in heart valve engineering, cell sources for harvesting, phenotypic expression in constructs and suitability in heart valve tissue engineering. Natural and synthetic biomaterials that have been applied as scaffold systems or cell-delivery platforms are discussed with each cell type.

AB - Heart valve tissue engineering is a promising alternative to prostheses for the replacement of diseased or damaged heart valves, because tissue-engineered valves have the ability to remodel, regenerate and grow. To engineer heart valves, cells are harvested, seeded onto or into a three-dimensional (3D) matrix platform to generate a tissue-engineered construct in vitro, and then implanted into a patient's body. Successful engineering of heart valves requires a thorough understanding of the different types of cells that can be used to obtain the essential phenotypes that are expressed in native heart valves. This article reviews different cell types that have been used in heart valve engineering, cell sources for harvesting, phenotypic expression in constructs and suitability in heart valve tissue engineering. Natural and synthetic biomaterials that have been applied as scaffold systems or cell-delivery platforms are discussed with each cell type.

KW - endothelial cell

KW - fibroblast

KW - heart valve

KW - interstitial cell

KW - myofibroblast

KW - stem cell

KW - tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=84990949474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84990949474&partnerID=8YFLogxK

U2 - 10.1002/term.2010

DO - 10.1002/term.2010

M3 - Review article

VL - 10

SP - 804

EP - 824

JO - Journal of Tissue Engineering and Regenerative Medicine

JF - Journal of Tissue Engineering and Regenerative Medicine

SN - 1932-6254

IS - 10

ER -