Abstract
Abstract: When membranes from neuroblastoma |MX glioma NG108–15 hybrid cells were incubated in a cell‐free system with opioid agonists, a time‐, temperature‐, and dose‐dependent desensitization to opioid inhibition of adenylate cyclase activity was observed. The composition of the system during the incubation was manipulated to elucidate the biochemical mechanisms of desensitization. Receptor coupling appeared to be a prerequisite for desensitization, because both magnesium and sodium, which are necessary for coupling, were required for desensitization. Removal of ATP and addition of cyclic AMP or cyclic GMP had no effect on desensitization.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 733-737 |
| Number of pages | 5 |
| Journal | Journal of Neurochemistry |
| Volume | 47 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1986 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Adenylate cyclase
- Desensitization
- Neuroblastoma |MX glioma hybrid cells
- Opioid
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