TY - JOUR
T1 - Cell surface markers and cellular immune response associated with rheumatic heart disease
T2 - Complex segregation analysis
AU - Rich, SS
AU - Gray, ED
AU - Talbot, R.
AU - Martin, D.
AU - Cairns, L.
AU - Zabriskie, JB
AU - Braun, D.
AU - Regelmann, WE
AU - Vogler, G. P.
PY - 1988
Y1 - 1988
N2 - A series of functional and cell surface markers associated with a significantly increased risk of rheumatic heart disease were analyzed for the contribution of genetic factors in their presence. Peripheral blood lymphocytes from nine large kindreds from the New Zealand Maori, Polynesian, and Caucasian populations were isolated, purified, and evaluated with lymphocyte surface markers (monoclonals 83S.19.23 and D8103), as well as studied for blastogenic response to a purified group A streptococcal extracellular product, blastogen A. Segregation analysis of blastogenic response and percent of cells positive for these cell surface markers was consistent with genetic control by single major genes; however, the contribution by polygenes varied by marker, indicating heterogeneity of genetic control of identification of cell surface glycoproteins and blastogenic response to streptococcal products.
AB - A series of functional and cell surface markers associated with a significantly increased risk of rheumatic heart disease were analyzed for the contribution of genetic factors in their presence. Peripheral blood lymphocytes from nine large kindreds from the New Zealand Maori, Polynesian, and Caucasian populations were isolated, purified, and evaluated with lymphocyte surface markers (monoclonals 83S.19.23 and D8103), as well as studied for blastogenic response to a purified group A streptococcal extracellular product, blastogen A. Segregation analysis of blastogenic response and percent of cells positive for these cell surface markers was consistent with genetic control by single major genes; however, the contribution by polygenes varied by marker, indicating heterogeneity of genetic control of identification of cell surface glycoproteins and blastogenic response to streptococcal products.
KW - blastogenic response
KW - family study
KW - lymphocyte binding
KW - rheumatic fever
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U2 - 10.1002/gepi.1370050610
DO - 10.1002/gepi.1370050610
M3 - Article
C2 - 3209057
AN - SCOPUS:0024272196
SN - 0741-0395
VL - 5
SP - 463
EP - 470
JO - Genetic epidemiology
JF - Genetic epidemiology
IS - 6
ER -
