Cell Reprogramming for Regeneration and Repair of the Nervous System

Isaac H. Clark, Alex Roman, Emily Fellows, Swathi Radha, Susanna R. Var, Zachary Roushdy, Samuel M. Borer, Samantha Johnson, Olivia Chen, Jacob S. Borgida, Aleta R Steevens, Anala Shetty, Phoebe Strell, Walter C. Low, Andrew W. Grande

Research output: Contribution to journalReview articlepeer-review

Abstract

A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various cell types through cellular reprogramming of native cells as a promising therapy to replenish lost or diminished cell populations in various neurological diseases. This review provides an in-depth analysis of the current viral vectors, genes of interest, and target cellular populations that have been studied, as well as the challenges and future directions of these novel therapies. Furthermore, the mechanisms by which cellular reprogramming could be optimized as treatment in neurological diseases and a review of the most recent cellular reprogramming in vitro and in vivo studies will also be discussed.

Original languageEnglish (US)
Article number2598
JournalBiomedicines
Volume10
Issue number10
DOIs
StatePublished - Oct 2022

Bibliographical note

Funding Information:
This work was funded in part by grants from the State of Minnesota Office of Higher Education, Spinal Cord Injury and Traumatic Brain Injury Research Program, and from the Suzanne M. Schwarz Fund.

Publisher Copyright:
© 2022 by the authors.

Keywords

  • cell-reprograming
  • gene therapies
  • neuro-regeneration

PubMed: MeSH publication types

  • Journal Article
  • Review

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