Cell Proliferation

N. Yang, S. D. Ray, K. Krafts

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations


Cell proliferation - the increase in cell numbers resulting from cell division - is a complex, tightly controlled, well-defined process. The mechanisms of normal cell proliferation, as well as the pathologic consequences occurring when the system malfunctions, are critical to many areas of medicine, from embryogenesis, to tissue repair, to oncogenesis. This article describes the normal process of cell division, including the cells involved, the normal series of steps that take places, and the growth factors and cytokines that mediate the process. Particular emphasis is placed on the crucial role cell proliferation plays in tissue repair following toxic injury.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Toxicology
Subtitle of host publicationThird Edition
Number of pages5
ISBN (Electronic)9780123864543
ISBN (Print)9780123864550
StatePublished - Jan 1 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.


  • Cancer
  • Cell cycle
  • Cell differentiation
  • Cell division
  • Cell proliferation
  • Cell senescence
  • Cytokines
  • Embryonic development
  • Growth factors
  • Stem cells
  • Tissue repair


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