Cell migration during heart regeneration in zebrafish

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Zebrafish possess the remarkable ability to regenerate injured hearts as adults, which contrasts the very limited ability in mammals. Although very limited, mammalian hearts do in fact have measurable levels of cardiomyocyte regeneration. Therefore, elucidating mechanisms of zebrafish heart regeneration would provide information of naturally occurring regeneration to potentially apply to mammalian studies, in addition to addressing this biologically interesting phenomenon in itself. Studies over the past 13 years have identified processes and mechanisms of heart regeneration in zebrafish. After heart injury, pre-existing cardiomyocytes dedifferentiate, enter the cell cycle, and repair the injured myocardium. This process requires interaction with epicardial cells, endocardial cells, and vascular endothelial cells. Epicardial cells envelope the heart, while endocardial cells make up the inner lining of the heart. They provide paracrine signals to cardiomyocytes to regenerate the injured myocardium, which is vascularized during heart regeneration. In addition, accumulating results suggest that local migration of these major cardiac cell types have roles in heart regeneration. In this review, we summarize the characteristics of various heart injury methods used in the research community and regeneration of the major cardiac cell types. Then, we discuss local migration of these cardiac cell types and immune cells during heart regeneration. Developmental Dynamics 245:774–787, 2016.

Original languageEnglish (US)
Pages (from-to)774-787
Number of pages14
JournalDevelopmental Dynamics
Volume245
Issue number7
DOIs
StatePublished - Jul 1 2016

Fingerprint

Zebrafish
Cell Movement
Regeneration
Cardiac Myocytes
Heart Injuries
Myocardium
Mammals
Cell Cycle
Endothelial Cells
Research

Keywords

  • cardiomyocytes
  • endocardial endothelial and vascular endothelial cells
  • epicardial cells
  • heart regeneration
  • local cell migration
  • zebrafish

Cite this

Cell migration during heart regeneration in zebrafish. / Tahara, Naoyuki; Brush, Michael; Kawakami, Yasuhiko.

In: Developmental Dynamics, Vol. 245, No. 7, 01.07.2016, p. 774-787.

Research output: Contribution to journalReview article

@article{0c760c85b2d64c18810fe6eb51706501,
title = "Cell migration during heart regeneration in zebrafish",
abstract = "Zebrafish possess the remarkable ability to regenerate injured hearts as adults, which contrasts the very limited ability in mammals. Although very limited, mammalian hearts do in fact have measurable levels of cardiomyocyte regeneration. Therefore, elucidating mechanisms of zebrafish heart regeneration would provide information of naturally occurring regeneration to potentially apply to mammalian studies, in addition to addressing this biologically interesting phenomenon in itself. Studies over the past 13 years have identified processes and mechanisms of heart regeneration in zebrafish. After heart injury, pre-existing cardiomyocytes dedifferentiate, enter the cell cycle, and repair the injured myocardium. This process requires interaction with epicardial cells, endocardial cells, and vascular endothelial cells. Epicardial cells envelope the heart, while endocardial cells make up the inner lining of the heart. They provide paracrine signals to cardiomyocytes to regenerate the injured myocardium, which is vascularized during heart regeneration. In addition, accumulating results suggest that local migration of these major cardiac cell types have roles in heart regeneration. In this review, we summarize the characteristics of various heart injury methods used in the research community and regeneration of the major cardiac cell types. Then, we discuss local migration of these cardiac cell types and immune cells during heart regeneration. Developmental Dynamics 245:774–787, 2016.",
keywords = "cardiomyocytes, endocardial endothelial and vascular endothelial cells, epicardial cells, heart regeneration, local cell migration, zebrafish",
author = "Naoyuki Tahara and Michael Brush and Yasuhiko Kawakami",
year = "2016",
month = "7",
day = "1",
doi = "10.1002/dvdy.24411",
language = "English (US)",
volume = "245",
pages = "774--787",
journal = "Developmental Dynamics",
issn = "1058-8388",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - Cell migration during heart regeneration in zebrafish

AU - Tahara, Naoyuki

AU - Brush, Michael

AU - Kawakami, Yasuhiko

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Zebrafish possess the remarkable ability to regenerate injured hearts as adults, which contrasts the very limited ability in mammals. Although very limited, mammalian hearts do in fact have measurable levels of cardiomyocyte regeneration. Therefore, elucidating mechanisms of zebrafish heart regeneration would provide information of naturally occurring regeneration to potentially apply to mammalian studies, in addition to addressing this biologically interesting phenomenon in itself. Studies over the past 13 years have identified processes and mechanisms of heart regeneration in zebrafish. After heart injury, pre-existing cardiomyocytes dedifferentiate, enter the cell cycle, and repair the injured myocardium. This process requires interaction with epicardial cells, endocardial cells, and vascular endothelial cells. Epicardial cells envelope the heart, while endocardial cells make up the inner lining of the heart. They provide paracrine signals to cardiomyocytes to regenerate the injured myocardium, which is vascularized during heart regeneration. In addition, accumulating results suggest that local migration of these major cardiac cell types have roles in heart regeneration. In this review, we summarize the characteristics of various heart injury methods used in the research community and regeneration of the major cardiac cell types. Then, we discuss local migration of these cardiac cell types and immune cells during heart regeneration. Developmental Dynamics 245:774–787, 2016.

AB - Zebrafish possess the remarkable ability to regenerate injured hearts as adults, which contrasts the very limited ability in mammals. Although very limited, mammalian hearts do in fact have measurable levels of cardiomyocyte regeneration. Therefore, elucidating mechanisms of zebrafish heart regeneration would provide information of naturally occurring regeneration to potentially apply to mammalian studies, in addition to addressing this biologically interesting phenomenon in itself. Studies over the past 13 years have identified processes and mechanisms of heart regeneration in zebrafish. After heart injury, pre-existing cardiomyocytes dedifferentiate, enter the cell cycle, and repair the injured myocardium. This process requires interaction with epicardial cells, endocardial cells, and vascular endothelial cells. Epicardial cells envelope the heart, while endocardial cells make up the inner lining of the heart. They provide paracrine signals to cardiomyocytes to regenerate the injured myocardium, which is vascularized during heart regeneration. In addition, accumulating results suggest that local migration of these major cardiac cell types have roles in heart regeneration. In this review, we summarize the characteristics of various heart injury methods used in the research community and regeneration of the major cardiac cell types. Then, we discuss local migration of these cardiac cell types and immune cells during heart regeneration. Developmental Dynamics 245:774–787, 2016.

KW - cardiomyocytes

KW - endocardial endothelial and vascular endothelial cells

KW - epicardial cells

KW - heart regeneration

KW - local cell migration

KW - zebrafish

UR - http://www.scopus.com/inward/record.url?scp=84966570064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966570064&partnerID=8YFLogxK

U2 - 10.1002/dvdy.24411

DO - 10.1002/dvdy.24411

M3 - Review article

VL - 245

SP - 774

EP - 787

JO - Developmental Dynamics

JF - Developmental Dynamics

SN - 1058-8388

IS - 7

ER -