Cell cycle regulators and lineage-specific therapeutic targets for cushing disease

Takako Araki, Ning Ai Liu

Research output: Contribution to journalShort survey

1 Scopus citations

Abstract

Cell cycle proteins are critical to pituitary development, but their contribution to lineage-specific tumorigenesis has not been well-elucidated. Emerging evidence from in vitro human tumor analysis and transgenic mouse models indicates that G1/S-related cell cycle proteins, particularly cyclin E, p27, Rb, and E2F1, drive molecular mechanisms that underlie corticotroph-specific differentiation and development of Cushing disease. The aim of this review is to summarize the literature and discuss the complex role of cell cycle regulation in Cushing disease, with a focus on identifying potential targets for therapeutic intervention in patients with these tumors.

Original languageEnglish (US)
Article number444
JournalFrontiers in Endocrinology
Volume9
Issue numberAUG
DOIs
StatePublished - Aug 10 2018

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Keywords

  • Cell cycle
  • Cushing disease
  • Cyclin E
  • E2F1
  • POMC
  • Pituitary tumor

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