Cell cycle regulators and lineage-specific therapeutic targets for cushing disease

Takako Araki, Ning Ai Liu

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Cell cycle proteins are critical to pituitary development, but their contribution to lineage-specific tumorigenesis has not been well-elucidated. Emerging evidence from in vitro human tumor analysis and transgenic mouse models indicates that G1/S-related cell cycle proteins, particularly cyclin E, p27, Rb, and E2F1, drive molecular mechanisms that underlie corticotroph-specific differentiation and development of Cushing disease. The aim of this review is to summarize the literature and discuss the complex role of cell cycle regulation in Cushing disease, with a focus on identifying potential targets for therapeutic intervention in patients with these tumors.

Original languageEnglish (US)
Article number444
JournalFrontiers in Endocrinology
Issue numberAUG
StatePublished - Aug 10 2018

Bibliographical note

Funding Information:
The authors thank Shira Berman for technical advice and assistance. This work was supported by NIH grants R21DK103198 (N-AL) and T32DK007770 (TA). The funding sources had no role in study design, data analysis, or decision to publish.

Publisher Copyright:
© 2018 Araki and Liu.


  • Cell cycle
  • Cushing disease
  • Cyclin E
  • E2F1
  • POMC
  • Pituitary tumor


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