Cell cycle regulation by protein degradation

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations


Cell division is controlled by a highly regulated program to accurately duplicate and segregate chromosomes. An important feature of the cell cycle regulatory program is that key cell cycle proteins are present and active during specific cell cycle stages but are later removed or inhibited to maintain appropriate timing. The ubiquitin-proteasome system has emerged as an important mechanism to target cell cycle proteins for degradation at critical junctures during cell division. Two key E3 ubiquitin ligase complexes that target key cell cycle proteins are the Skp1-Cul1-F-box protein complex and the anaphase-promoting complex/cyclosome. This chapter focuses on the role of these E3 ubiquitin ligases and how ubiquitin-dependent degradation of central cell cycle regulatory proteins advances the cell cycle.

Original languageEnglish (US)
Title of host publicationCell Cycle Control
Subtitle of host publicationMechanisms and Protocols
PublisherHumana Press Inc.
Number of pages13
ISBN (Print)9781493908875
StatePublished - 2014

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Anaphase-promoting complex
  • Cell cycle
  • Cyclin
  • Cyclin-dependent kinase
  • Cyclosome
  • Proteasome
  • Skp1/Cul1/F-box protein complex
  • Ubiquitin
  • Ubiquitin ligase


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