TY - JOUR
T1 - Cell culture bioprocessing — the road taken and the path forward
AU - O'Brien, Sofie A.
AU - Hu, Wei Shou
N1 - Funding Information:
SAO was supported in part by the NIGMS Biotechnology Training Program ( T32GM008347-22) . This work was supported in part by NIIMBL PC2.1-042 .
PY - 2020
Y1 - 2020
N2 - Cell culture processes are used to produce the vast majority of protein therapeutics, valued at over US$180 billion per annum worldwide. For more than a decade now, these processes have become highly productive. To further enhance capital efficiency, there has been an increase in the adoption of disposable apparatus and continuous processing, as well as a greater exploration of in-line sensing, various -omic tools, and cell engineering to enhance process controllability and product quality consistency. These feats in cell culture processing for protein biologics will help accelerate the bioprocess advancements for virus and cell therapy applications.
AB - Cell culture processes are used to produce the vast majority of protein therapeutics, valued at over US$180 billion per annum worldwide. For more than a decade now, these processes have become highly productive. To further enhance capital efficiency, there has been an increase in the adoption of disposable apparatus and continuous processing, as well as a greater exploration of in-line sensing, various -omic tools, and cell engineering to enhance process controllability and product quality consistency. These feats in cell culture processing for protein biologics will help accelerate the bioprocess advancements for virus and cell therapy applications.
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U2 - 10.1016/j.coche.2020.100663
DO - 10.1016/j.coche.2020.100663
M3 - Review article
AN - SCOPUS:85096989949
JO - Current Opinion in Chemical Engineering
JF - Current Opinion in Chemical Engineering
SN - 2211-3398
M1 - 100663
ER -