Cell culture bioprocessing — the road taken and the path forward

Sofie A. O'Brien, Wei Shou Hu

Research output: Contribution to journalReview articlepeer-review


Cell culture processes are used to produce the vast majority of protein therapeutics, valued at over US$180 billion per annum worldwide. For more than a decade now, these processes have become highly productive. To further enhance capital efficiency, there has been an increase in the adoption of disposable apparatus and continuous processing, as well as a greater exploration of in-line sensing, various -omic tools, and cell engineering to enhance process controllability and product quality consistency. These feats in cell culture processing for protein biologics will help accelerate the bioprocess advancements for virus and cell therapy applications.

Original languageEnglish (US)
Article number100663
JournalCurrent Opinion in Chemical Engineering
StateAccepted/In press - 2020

Bibliographical note

Funding Information:
SAO was supported in part by the NIGMS Biotechnology Training Program ( T32GM008347-22) . This work was supported in part by NIIMBL PC2.1-042 .

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