Cell behaviour of calcium phosphate bone cement modified with a protein-based foaming agent

E. Engel, L. Asin, J. A. Delgado, C. Aparicio, J. A. Planell, M. P. Ginebra

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Calcium phosphate cements (CPC) are being applied as bone regeneration materials. New methods are being developed to create macroporosity, in order enhance the angiogenesis, bone colonization and biodegradation of the material. In this study the effect of the incorporation of albumen as foaming agent in an α-tricalcium phosphate (α-TCP) cement, in terms of the surface roughness and in vitro cell response, was studied. The addition of albumen to CPC cements increased the surface roughness of the cements. Cell cultures, using MG63 osteoblasts, were performed and showed that cell attachment was not affected by the presence of albumen. However, cell proliferation was significantly increased in the albumen-containing cements.

Original languageEnglish (US)
Pages (from-to)117-120
Number of pages4
JournalKey Engineering Materials
Volume284-286
DOIs
StatePublished - Jan 1 2005

Keywords

  • Biocompatibility
  • Bone grafts
  • Calcium phosphate cement
  • Osteoblasts

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