Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity

B. A.B. Leonard, P. K. Lee, M. K. Jenkins, P. M. Schlievert

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Streptococcal pyrogenic exotoxins (SPEs) A, B, and C, like other members of the pyrogenic toxin family, are able to cause toxic shock-like syndromes. One of the major properties of these toxins is the ability to induce T-cell proliferation. Characterization of T cell mitogenicity associated with SPEs A, B, and C was undertaken. SPEs A, B, and C were mitogenic for C57BL10/SnJ and BALB/cWAT T cells, with activities differing in intensity depending on the mouse strain and toxin employed. SPE-induced, T-cell-proliferative activity was dependent on class II major histocompatibility complex molecules expressed on antigen-presnting cells. The abilities of SPEs A, B, and C to preferentially stimulate murine cells with certain T-cell receptor Vβs were investigated by fluorescence-activated cell sorter analysis. SPE A preferentially activated T cells expressing Vβ 8 but Vβ 3, 6, or 11, while SPEs B and C preferentially stimulated T cells which did not express any of the tested Vβs.

Original languageEnglish (US)
Pages (from-to)1210-1214
Number of pages5
JournalInfection and immunity
Volume59
Issue number3
StatePublished - 1991

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