CD8+ T cell tolerance: It doesn't translate

Katharine E. Block; Stephen C. Jameson

doi:10.1016/j.immuni.2024.05.014

CD8⁺ T cell tolerance: It doesn't translate

Katharine E. Block, Stephen C. Jameson

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

The mechanisms that make and break CD8⁺ T cell tolerance to self-antigens remain unclear. In this issue of Immunity, Van Der Byl et al. show that tolerant CD8⁺ T cells rapidly adopt an epigenetically and transcriptionally distinct cell state and exhibit impaired protein translation. Breaking tolerance requires both inflammation and increased antigen exposure to augment MYC expression and restore translation.

Original language	English (US)
Pages (from-to)	1184-1186
Number of pages	3
Journal	Immunity
Volume	57
Issue number	6
DOIs	https://doi.org/10.1016/j.immuni.2024.05.014
State	Published - Jun 11 2024

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Publisher Copyright:
© 2024 Elsevier Inc.

PubMed: MeSH publication types

Journal Article
Comment

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10.1016/j.immuni.2024.05.014

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title = "CD8+ T cell tolerance: It doesn't translate",

abstract = "The mechanisms that make and break CD8+ T cell tolerance to self-antigens remain unclear. In this issue of Immunity, Van Der Byl et al. show that tolerant CD8+ T cells rapidly adopt an epigenetically and transcriptionally distinct cell state and exhibit impaired protein translation. Breaking tolerance requires both inflammation and increased antigen exposure to augment MYC expression and restore translation.",

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year = "2024",

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