CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine

Julie M. Curtsinger, Christopher M. Johnson, Matthew F. Mescher

Research output: Contribution to journalArticlepeer-review

206 Scopus citations

Abstract

Full activation of naive CD8 T cells requires Ag, costimulation, and a third signal that can be provided by IL-12. Brief exposure (6 h) to Ag and B7-1 is sufficient to stimulate multiple rounds of cell division, but clonal expansion and development of effector function are minimal even when signal 3 is present. Full activation instead requires concerted signaling by Ag, B7-1, and IL-12 for greater than 40 h. Thus, the gene expression program required for cell division can be initiated by brief interaction with Ag and costimulation, but maintaining the expression of the genes needed for survival and effector function requires prolonged signaling by a signal 3 cytokine in concert with Ag and costimulation.

Original languageEnglish (US)
Pages (from-to)5165-5171
Number of pages7
JournalJournal of Immunology
Volume171
Issue number10
DOIs
StatePublished - Nov 15 2003

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