Cd8 and antigen-specific t cell adhesion cascades

Anne M. O’Rourke, Belen Ybarrondo, Matthew F. Mescher

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Activation of T cells involves both the antigen-specific T cell receptor and a number of additional accessory receptors. For cytotoxic T lymphocytes these include CD8, LFA-1 and VLA receptors. Recent studies have demonstrated that these receptors become activated to mediate adhesion upon crosslinking of the T cell receptor, and can deliver co-stimulatory signals upon binding their ligands. Rather than being redundant adhesion/co-signalling systems, these various receptors participate in a cascade of adhesion and signalling events leading to full activation of cellular responses.

Original languageEnglish (US)
Pages (from-to)263-270
Number of pages8
JournalSeminars in Immunology
Volume5
Issue number4
DOIs
StatePublished - Aug 1993

Keywords

  • CD8
  • Class I antigen
  • Cytotoxic T lymphocyte
  • Fibronectin
  • ICAM-1

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