CD4+ T cells coexpressing CD134 (OX40) harbor significantly increased levels of human herpesvirus 6b DNA following umbilical cord blood transplantation

Joshua C. Pritchett; Jaime S. Green; Angela M. Thomm; Konstance K. Knox; Michael R. Verneris; Troy C. Lund

doi:10.1093/infdis/jiw469

CD4⁺ T cells coexpressing CD134 (OX40) harbor significantly increased levels of human herpesvirus 6b DNA following umbilical cord blood transplantation

Joshua C. Pritchett, Jaime S. Green, Angela M. Thomm, Konstance K. Knox, Michael R. Verneris, Troy C. Lund

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4⁺CD134^+/neg-lo and CD8⁺CD134⁺/neg-lo cells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4+CD134+ cells as compared to CD4⁺CD134neg-lo cells showed 0.308 versus 0.129 copies of HHV-6B/cell (P = .0002). CD8⁺CD134^+/neg-lo cells contained little to no HHV-6B copies. Following UCBT, CD4⁺CD134⁺ cells harbor significantly increased levels of HHV-6B, suggesting that CD134 (OX40) may facilitate viral entry.

Original language	English (US)
Pages (from-to)	1911-1915
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	214
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiw469
State	Published - Dec 1 2016

Bibliographical note

Funding Information:
Financial support. This work was supported by the American Society of Hematology (Hematology Opportunities for the Next Generation of Research Scientists grant to J. C. P.) and the National Institutes of Health (grants RO1AI100879 [to M. R. V.] and PO1CA065493 [to M. R. V.]).

Publisher Copyright:
© The Author 2016.

Keywords

CD134
HHV-6
Herpesvirus
OX40
Umbilical cord blood transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiw469

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title = "CD4+ T cells coexpressing CD134 (OX40) harbor significantly increased levels of human herpesvirus 6b DNA following umbilical cord blood transplantation",

abstract = "Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4+CD134+/neg-lo and CD8+CD134+/neg-lo cells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4+CD134+ cells as compared to CD4+CD134neg-lo cells showed 0.308 versus 0.129 copies of HHV-6B/cell (P = .0002). CD8+CD134+/neg-lo cells contained little to no HHV-6B copies. Following UCBT, CD4+CD134+ cells harbor significantly increased levels of HHV-6B, suggesting that CD134 (OX40) may facilitate viral entry.",

keywords = "CD134, HHV-6, Herpesvirus, OX40, Umbilical cord blood transplantation",

author = "Pritchett, {Joshua C.} and Green, {Jaime S.} and Thomm, {Angela M.} and Knox, {Konstance K.} and Verneris, {Michael R.} and Lund, {Troy C.}",

note = "Funding Information: Financial support. This work was supported by the American Society of Hematology (Hematology Opportunities for the Next Generation of Research Scientists grant to J. C. P.) and the National Institutes of Health (grants RO1AI100879 [to M. R. V.] and PO1CA065493 [to M. R. V.]). Publisher Copyright: {\textcopyright} The Author 2016.",

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AU - Thomm, Angela M.

AU - Knox, Konstance K.

AU - Verneris, Michael R.

AU - Lund, Troy C.

N1 - Funding Information: Financial support. This work was supported by the American Society of Hematology (Hematology Opportunities for the Next Generation of Research Scientists grant to J. C. P.) and the National Institutes of Health (grants RO1AI100879 [to M. R. V.] and PO1CA065493 [to M. R. V.]). Publisher Copyright: © The Author 2016.

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N2 - Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4+CD134+/neg-lo and CD8+CD134+/neg-lo cells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4+CD134+ cells as compared to CD4+CD134neg-lo cells showed 0.308 versus 0.129 copies of HHV-6B/cell (P = .0002). CD8+CD134+/neg-lo cells contained little to no HHV-6B copies. Following UCBT, CD4+CD134+ cells harbor significantly increased levels of HHV-6B, suggesting that CD134 (OX40) may facilitate viral entry.

AB - Human herpesvirus 6B (HHV-6B) commonly reactivates after umbilical cord blood transplantation (UCBT) and is associated with delayed engraftment, fever, rash, and central nervous system dysfunction. Recently, CD134 (OX40) has been implicated as a potential viral entry receptor. We evaluated CD4+CD134+/neg-lo and CD8+CD134+/neg-lo cells at day 28 after UCBT in 20 subjects with previously documented HHV-6 reactivation and persistent viremia. Analysis of CD4+CD134+ cells as compared to CD4+CD134neg-lo cells showed 0.308 versus 0.129 copies of HHV-6B/cell (P = .0002). CD8+CD134+/neg-lo cells contained little to no HHV-6B copies. Following UCBT, CD4+CD134+ cells harbor significantly increased levels of HHV-6B, suggesting that CD134 (OX40) may facilitate viral entry.

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