CD4+ memory T cell survival

Justin J. Taylor, Marc K. Jenkins

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Memory CD4+ T cells specific for a given antigen are generated during the primary response from the effector lymphoblast progeny of naïve precursors. How memory CD4+ T cells differentiate from the effector population is not understood but new tools to assess transcription factor and cytokine expression are allowing for a more careful assessment of this process. Here we review the factors that allow some effector CD4+ T cells to survive the contraction phase of the primary response and become memory cells, and consider whether parallels can be drawn between T and B cells.

Original languageEnglish (US)
Pages (from-to)319-323
Number of pages5
JournalCurrent Opinion in Immunology
Issue number3
StatePublished - Jun 2011


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