CD43 is associated with tyrosine kinase activity in human neutrophils

Keith M Skubitz, Kenneth D. Campbell, Amy P Skubitz

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

CD43 appears to be involved in signal transduction, however, the mechanism of this function is unknown. Protein kinase activity was detected in neutrophils associated with CD43. Most of the protein kinase activity associated with these antigens was tyrosine kinase activity. The src family kinases lyn and hck were found to account for much of the associated tyrosine kinase activity. The data suggest that associated tyrosine kinase activity may play a role in signal transduction via CD43 to regulate other cell functions.

Original languageEnglish (US)
Pages (from-to)800-802
Number of pages3
JournalJournal of Leukocyte Biology
Volume64
Issue number6
DOIs
StatePublished - Dec 1998

Keywords

  • Granulocyte
  • Inflammation
  • Membrane protein
  • Protein kinase
  • Signal transduction

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