CD4+ T cells specific for factor VIII as a target for specific suppression of inhibitor production

M. T. Reding, H. Wu, M. Krampf, D. K. Okita, B. M. Diethelm-Okita, N. S. Key, B. M. Conti-Fine

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The studies we reviewed here have begun to clarify the complex cellular mechanisms involved in the immune response to fVIII, and the circumstances under which fVIII inhibitors develop. Further characterization and comparison of the immune response to fVIII in both hemophilia patients and healthy subjects will help to further elucidate these mechanisms. The murine hemophilia model will hopefully provide further insights into the mechanisms of inhibitor formation, and prove to be a suitable tool for the design and testing of therapeutic strategies aimed at preventing the development of fVIII inhibitors.

Original languageEnglish (US)
Pages (from-to)119-134
Number of pages16
JournalAdvances in experimental medicine and biology
Volume489
DOIs
StatePublished - 2001

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