CD4 T cell count reconstitution in HIV controllers after highly active antiretroviral therapy

Jason F. Okulicz, Greg A. Grandits, Amy C. Weintrob, Michael L. Landrum, Anuradha Ganesan, Nancy F. Crum-Cianflone, Brian K. Agan, Vincent C. Marconi

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Sixty-two human immunodeficiency virus (HIV) controllers (6 elite and 56 viremic controllers) in the US Military Department of Defense HIV Natural History Study cohort initiated highly active antiretroviral therapy (HAART) and achieved statistically significant mean CD4 cell count increases, although the gains were lower than those in treated noncontrollers. HIV controllers experienced CD4 cell count reconstitution with HAART regardless of pretherapy viral load, including patients with undetectable viral loads at HAART initiation

Original languageEnglish (US)
Pages (from-to)1187-1191
Number of pages5
JournalClinical Infectious Diseases
Volume50
Issue number8
DOIs
StatePublished - Apr 15 2010

Bibliographical note

Funding Information:
Financial support. Support for this work (IDCRP-000-05) was provided by the Infectious Disease Clinical Research Program, a Department of Defense program executed through the Uniformed Services University of the Health Sciences. This project has been funded in whole or in part with federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, under interagency agreement Y1-AI-5072. Potential conflicts of interest. All authors: no conflicts.

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

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