TY - JOUR
T1 - CD4 + T cells and HIV
T2 - A paradoxical pas de deux
AU - Klatt, Nichole R.
AU - Silvestri, Guido
PY - 2012/2/29
Y1 - 2012/2/29
N2 - When it comes to HIV infection, CD4 + T cells are usually thought of as the cells that are preferentially infected and killed by the virus. In a new study, Soghoian et al. now show that during the early stages of HIV infection, CD4 + T cells suppress virus replication and delay disease onset. Thus, the robustness of the CD4 + T cell response during early HIV infection could be used as a marker to determine the speed of disease progression. The new findings also have implications for the design of preventive and therapeutic AIDS vaccines.
AB - When it comes to HIV infection, CD4 + T cells are usually thought of as the cells that are preferentially infected and killed by the virus. In a new study, Soghoian et al. now show that during the early stages of HIV infection, CD4 + T cells suppress virus replication and delay disease onset. Thus, the robustness of the CD4 + T cell response during early HIV infection could be used as a marker to determine the speed of disease progression. The new findings also have implications for the design of preventive and therapeutic AIDS vaccines.
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U2 - 10.1126/scitranslmed.3003862
DO - 10.1126/scitranslmed.3003862
M3 - Review article
C2 - 22378922
AN - SCOPUS:84857731632
SN - 1946-6234
VL - 4
JO - Science Translational Medicine
JF - Science Translational Medicine
IS - 123
M1 - 123ps4
ER -
