CD4 + T cells and HIV: A paradoxical pas de deux

Nichole R. Klatt, Guido Silvestri

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


When it comes to HIV infection, CD4 + T cells are usually thought of as the cells that are preferentially infected and killed by the virus. In a new study, Soghoian et al. now show that during the early stages of HIV infection, CD4 + T cells suppress virus replication and delay disease onset. Thus, the robustness of the CD4 + T cell response during early HIV infection could be used as a marker to determine the speed of disease progression. The new findings also have implications for the design of preventive and therapeutic AIDS vaccines.

Original languageEnglish (US)
Article number123ps4
JournalScience Translational Medicine
Issue number123
StatePublished - Feb 29 2012
Externally publishedYes


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