TY - JOUR
T1 - CD38/cyclic ADP-ribose signaling
T2 - Role in the regulation of calcium homeostasis in airway smooth muscle
AU - Deshpande, Deepak A.
AU - White, Thomas A.
AU - Dogan, Soner
AU - Walseth, Timothy F.
AU - Panettieri, Reynold A.
AU - Kannan, Mathur S.
PY - 2005/5
Y1 - 2005/5
N2 - The contractility of airway smooth muscle cells is dependent on dynamic changes in the concentration of intracellular calcium. Signaling molecules such as inositol 1,4,5-trisphosphate and cyclic ADP-ribose play pivotal roles in the control of intracellular calcium concentration. Alterations in the processes involved in the regulation of intracellular calcium concentration contribute to the pathogenesis of airway diseases such as asthma. Recent studies have identified cyclic ADP-ribose as a calcium-mobilizing second messenger in airway smooth muscle cells, and modulation of the pathway involved in its metabolism results in altered calcium homeostasis and may contribute to airway hyperresponsiveness. In this review, we describe the basic mechanisms underlying the dynamics of calcium regulation and the role of CD38/cADPR, a novel pathway, in the context of airway smooth muscle function and its contribution to airway diseases such as asthma.
AB - The contractility of airway smooth muscle cells is dependent on dynamic changes in the concentration of intracellular calcium. Signaling molecules such as inositol 1,4,5-trisphosphate and cyclic ADP-ribose play pivotal roles in the control of intracellular calcium concentration. Alterations in the processes involved in the regulation of intracellular calcium concentration contribute to the pathogenesis of airway diseases such as asthma. Recent studies have identified cyclic ADP-ribose as a calcium-mobilizing second messenger in airway smooth muscle cells, and modulation of the pathway involved in its metabolism results in altered calcium homeostasis and may contribute to airway hyperresponsiveness. In this review, we describe the basic mechanisms underlying the dynamics of calcium regulation and the role of CD38/cADPR, a novel pathway, in the context of airway smooth muscle function and its contribution to airway diseases such as asthma.
KW - 12.6-kDa FK506-binding protein
KW - Calcium oscillations
KW - Inflammatory cytokines
KW - Muscarinic receptors
KW - Ryanodine receptor
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U2 - 10.1152/ajplung.00217.2004
DO - 10.1152/ajplung.00217.2004
M3 - Review article
C2 - 15821018
AN - SCOPUS:17444412638
SN - 0363-6143
VL - 288
SP - L773-L788
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
IS - 5 32-5
ER -