CD38/cADPR Signaling Pathway in Airway Disease

Regulatory Mechanisms

Deepak A. Deshpande, Alonso Guedes, Richard M Graeff, Soner Dogan, Subree Subramanian, Timothy F Walseth, Mathur S Kannan

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness. Inflammatory cytokines alter calcium (Ca2+) signaling and contractility of airway smooth muscle, which results in nonspecific airway hyperresponsiveness to agonists. In this context, Ca2+ regulatory mechanisms in airway smooth muscle and changes in these regulatory mechanisms encompass a major component of airway hyperresponsiveness. Although dynamic Ca2+ regulation is complex, phospholipase C/inositol tris-phosphate (PLC/IP3) and CD38-cyclic ADP-ribose (CD38/cADPR) are two major pathways mediating agonist-induced Ca2+ regulation in airway smooth muscle. Altered CD38 expression or enhanced cyclic ADP-ribosyl cyclase activity associated with CD38 contributes to human pathologies such as asthma, neoplasia, and neuroimmune diseases. This review is focused on investigations on the role of CD38-cyclic ADP-ribose signaling in airway smooth muscle in the context of transcriptional and posttranscriptional regulation of CD38 expression. The specific roles of transcription factors NF-kB and AP-1 in the transcriptional regulation of CD38 expression and of miRNAs miR-140-3p and miR-708 in the posttranscriptional regulation and the underlying mechanisms of such regulation are discussed.

Original languageEnglish (US)
Article number8942042
JournalMediators of inflammation
Volume2018
DOIs
StatePublished - Jan 1 2018

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Cyclic ADP-Ribose
Smooth Muscle
ADP-ribosyl Cyclase
Asthma
Cytokines
Inositol Phosphates
Calcium Signaling
NF-kappa B
Transcription Factor AP-1
Type C Phospholipases
MicroRNAs
Pathology
Neoplasms

PubMed: MeSH publication types

  • Journal Article
  • Review

Cite this

CD38/cADPR Signaling Pathway in Airway Disease : Regulatory Mechanisms. / Deshpande, Deepak A.; Guedes, Alonso; Graeff, Richard M; Dogan, Soner; Subramanian, Subree; Walseth, Timothy F; Kannan, Mathur S.

In: Mediators of inflammation, Vol. 2018, 8942042, 01.01.2018.

Research output: Contribution to journalReview article

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