CD38 in the pathogenesis of allergic airway disease: Potential therapeutic targets

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

CD38 is an ectoenzyme that catalyzes the conversion of β-nicotinamide adenine dinucleotide (β-NAD) to cyclic adenosine diphosphoribose (cADPR) and adenosine diphosphoribose (ADPR) and NADP to nicotinic acid adenine dinucleotide phosphate (NAADP) and adenosine diphosphoribose-2′-phosphate (ADPR-P). The metabolites of NAD and NADP have roles in calcium signaling in different cell types including airway smooth muscle (ASM) cells. In ASM cells, inflammatory cytokines augment CD38 expression and to a greater magnitude in cells from asthmatics, indicating a greater capacity for the generation of cADPR and ADPR in ASM from asthmatics. CD38 deficient mice develop attenuated airway responsiveness to inhaled methacholine following allergen sensitization and challenge compared to wild-type mice indicating its potential role in asthma. Regulation of CD38 expression in ASM cells is achieved by mitogen activated protein kinases, specific isoforms of PI3 kinases, the transcription factors NF-κB and AP-1, and post-transcriptionally by microRNAs. This review will focus on the role of CD38 in intracellular calcium regulation in ASM, contribution to airway inflammation and airway hyperresponsiveness in mouse models of allergic airway inflammation, the transcriptional and post-transcriptional mechanisms of regulation of expression, and outline approaches to inhibit its expression and activity.

Original languageEnglish (US)
Pages (from-to)116-126
Number of pages11
JournalPharmacology and Therapeutics
Volume172
DOIs
StatePublished - Apr 1 2017

Fingerprint

Adenosine Diphosphate Ribose
Smooth Muscle Myocytes
NADP
NAD
Smooth Muscle
Inflammation
Therapeutics
Calcium Signaling
Methacholine Chloride
Transcription Factor AP-1
Adenosine Monophosphate
Mitogen-Activated Protein Kinases
MicroRNAs
Phosphatidylinositol 3-Kinases
Allergens
Protein Isoforms
Transcription Factors
Asthma
Cytokines
Calcium

Keywords

  • Airway smooth muscle
  • Asthma
  • CD38
  • Calcium regulation
  • MicroRNAs

Cite this

CD38 in the pathogenesis of allergic airway disease : Potential therapeutic targets. / Deshpande, Deepak A.; Guedes, Alonso G P; Lund, Frances E.; Subramanian, Subbaya; Walseth, Timothy F.; Kannan, Mathur S.

In: Pharmacology and Therapeutics, Vol. 172, 01.04.2017, p. 116-126.

Research output: Contribution to journalReview article

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