CD163 Expression was associated with angiogenesis and shortened survival in patients with uniformly treated classical Hodgkin lymphoma

Young Wha Koh, Chan Sik Park, Dok Hyun Yoon, Cheolwon Suh, Jooryung Huh

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Background: Recent studies have reported the prognostic value of tissue-associated magrophages (TAMs) in classical Hodgkin lymphoma (cHL). In addition, TAMs are implicated in the tumor angiogenesis. In this study, we examined the prognostic relevance of TAMs in relation to vascular endothelial growth factor (VEGF) expression and angiogenesis in uniformly treated cases of cHL. Methods: Diagnostic tissue from 116 patients with ABVD-treated cHL was evaluated retrospectively by immunohistochemical analysis for CD68, CD163 and VEGF expression and for CD31 expression as a measure of microvessel density (MVD). Results: High CD163 expression (≥35% of cellularity) correlated with VEGF expression (Pearson's Chi-square test, P = 0.008) and MVD (Spearman correlation coefficient 0.310, P<0.001). High CD163 expression was associated with inferior event-free survival (EFS, P = 0.005) and overall survival (OS, P<0.001) in univariate analysis. In multivariate analysis, high CD163 expression was strongly associated with inferior EFS (P = 0.043) and OS (P = 0.008). Patients with high MVD had a lower OS than those with low MVD, but the difference was not significant (P = 0.071, respectively). While high expression of CD68 was also associated with inferior EFS (P = 0.007), it showed no correlation with VEGF or MVD. Conclusions: Our data confirms that CD163 expression provides independent prognostic information in cHL. The correlation of CD163 with VEGF expression and MVD suggests the role of CD163-positive cells in tumor angiogenesis of cHL.

Original languageEnglish (US)
Article numbere87066
JournalPloS one
Volume9
Issue number1
DOIs
StatePublished - Jan 29 2014

Fingerprint Dive into the research topics of 'CD163 Expression was associated with angiogenesis and shortened survival in patients with uniformly treated classical Hodgkin lymphoma'. Together they form a unique fingerprint.

Cite this