Abstract
Objectives: CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. Methods: Retrospective review of T-PLL cases with complete flow cytometry data including CD161. Results: We identified 10 cases of T-PLL with flow cytometric evaluation of CD161 available. Six of these cases were positive for CD161 expression. All CD161-positive cases were positive for CD8 with variable CD4 expression, whereas all CD161-negative cases were negative for CD8. In a case with two neoplastic subsets positive and negative for CD8, only the former expressed CD161. Conclusions: These novel results suggest that CD161 is often aberrantly expressed in a defined subset of T-PLL positive for CD8. We are showing the utility of this immunophenotype in diagnosis and follow-up.
Original language | English (US) |
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Pages (from-to) | 471-478 |
Number of pages | 8 |
Journal | American journal of clinical pathology |
Volume | 152 |
Issue number | 4 |
DOIs | |
State | Published - Sep 9 2019 |
Bibliographical note
Publisher Copyright:© 2019 American Society for Clinical Pathology, 2019. All rights reserved. For permissions, please e-mail: [email protected].
Keywords
- CD161
- Flow cytometry
- Immunophenotype
- NKR-P1A
- T-cell lymphoma
- T-cell prolymphocytic leukemia