CD14 receptor-mediated uptake of nonopsonized Mycobacterium tuberculosis by human microglia

P. K. Peterson, G. Gekker, S. Hu, W. S. Sheng, W. R. Anderson, R. J. Ulevitch, P. S. Tobias, K. V. Gustafson, T. W. Molitor, C. C. Chao

Research output: Contribution to journalArticlepeer-review

135 Scopus citations

Abstract

This study was carried out to determine the role of CD14 receptors in the uptake of nonopsonized Mycobacterium tuberculosis by human microglia. Treatment of microglial cell cultures with antibodies to CD14 or with soluble CD14 significantly blocked infection by M. tuberculosis H37Rv, suggesting that CD14 receptors could facilitate entry of nonopsonized tubercle bacilli into macrophages within the brain.

Original languageEnglish (US)
Pages (from-to)1598-1602
Number of pages5
JournalInfection and immunity
Volume63
Issue number4
DOIs
StatePublished - 1995

Fingerprint Dive into the research topics of 'CD14 receptor-mediated uptake of nonopsonized Mycobacterium tuberculosis by human microglia'. Together they form a unique fingerprint.

Cite this