CD14 receptor-mediated uptake of nonopsonized Mycobacterium tuberculosis by human microglia

P. K. Peterson; G. Gekker; S. Hu; W. S. Sheng; W. R. Anderson; R. J. Ulevitch; P. S. Tobias; K. V. Gustafson; T. W. Molitor; C. C. Chao

doi:10.1128/iai.63.4.1598-1602.1995

CD14 receptor-mediated uptake of nonopsonized Mycobacterium tuberculosis by human microglia

P. K. Peterson, G. Gekker, S. Hu, W. S. Sheng, W. R. Anderson, R. J. Ulevitch, P. S. Tobias, K. V. Gustafson, T. W. Molitor, C. C. Chao

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149 Scopus citations

Abstract

This study was carried out to determine the role of CD14 receptors in the uptake of nonopsonized Mycobacterium tuberculosis by human microglia. Treatment of microglial cell cultures with antibodies to CD14 or with soluble CD14 significantly blocked infection by M. tuberculosis H37Rv, suggesting that CD14 receptors could facilitate entry of nonopsonized tubercle bacilli into macrophages within the brain.

Original language	English (US)
Pages (from-to)	1598-1602
Number of pages	5
Journal	Infection and immunity
Volume	63
Issue number	4
DOIs	https://doi.org/10.1128/iai.63.4.1598-1602.1995
State	Published - 1995

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title = "CD14 receptor-mediated uptake of nonopsonized Mycobacterium tuberculosis by human microglia",

abstract = "This study was carried out to determine the role of CD14 receptors in the uptake of nonopsonized Mycobacterium tuberculosis by human microglia. Treatment of microglial cell cultures with antibodies to CD14 or with soluble CD14 significantly blocked infection by M. tuberculosis H37Rv, suggesting that CD14 receptors could facilitate entry of nonopsonized tubercle bacilli into macrophages within the brain.",

author = "Peterson, {P. K.} and G. Gekker and S. Hu and Sheng, {W. S.} and Anderson, {W. R.} and Ulevitch, {R. J.} and Tobias, {P. S.} and Gustafson, {K. V.} and Molitor, {T. W.} and Chao, {C. C.}",

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AU - Peterson, P. K.

AU - Gekker, G.

AU - Hu, S.

AU - Sheng, W. S.

AU - Anderson, W. R.

AU - Ulevitch, R. J.

AU - Tobias, P. S.

AU - Gustafson, K. V.

AU - Molitor, T. W.

AU - Chao, C. C.

PY - 1995

Y1 - 1995

N2 - This study was carried out to determine the role of CD14 receptors in the uptake of nonopsonized Mycobacterium tuberculosis by human microglia. Treatment of microglial cell cultures with antibodies to CD14 or with soluble CD14 significantly blocked infection by M. tuberculosis H37Rv, suggesting that CD14 receptors could facilitate entry of nonopsonized tubercle bacilli into macrophages within the brain.

AB - This study was carried out to determine the role of CD14 receptors in the uptake of nonopsonized Mycobacterium tuberculosis by human microglia. Treatment of microglial cell cultures with antibodies to CD14 or with soluble CD14 significantly blocked infection by M. tuberculosis H37Rv, suggesting that CD14 receptors could facilitate entry of nonopsonized tubercle bacilli into macrophages within the brain.

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EP - 1602

JO - Infection and immunity

JF - Infection and immunity

IS - 4

ER -

CD14 receptor-mediated uptake of nonopsonized Mycobacterium tuberculosis by human microglia

Abstract

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