Charruyer and colleagues (this issue) report two significant advances to the field of cutaneous keratinocyte stem cells: a pair of new selectable markers that recognize a subset of α6+ CD34+ label-retaining cells, and an in vivo limiting dilution assay for keratinocyte stem cells with long-term repopulating ability. This work has important implications for keratinocyte stem cell identification and assay, as well as for the identification of target cells in non-melanoma skin cancer.
Bibliographical noteFunding Information:
We thank Emily Majerus for carefully reading the manuscript and for her helpful suggestions. We apologize to our many excellent colleagues whose outstanding work we could not discuss or cite here because of the space limitations of this Commentary. Our effort was supported by NIAMS, NIH grant R01 AR05713, and by a Grant-in-Aid of Research, Artistry, and Scholarship from the Office of the Vice President for Research, University of Minnesota to RJM, and by NIEHS, NIH grant R21 ES020060 to DMO, and by NHLBI, NIH Ruth L. Kirschstein National Research Service Award Short-Term Institutional Research Training Grant T35 HL 007616 to ASN.