Caveolin regulation of neuronal intracellular signaling

Christopher M. Stern, Paul G. Mermelstein

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Caveolin proteins physically interact with and compartmentalize membrane-localized signaling proteins to facilitate high-fidelity intracellular signaling. Though primarily studied outside the nervous system, recent investigations have revealed that caveolin proteins are key modulators of a variety of neuronal intracellular signaling pathways. Through both protein aggregation and segregation, caveolin proteins can exert positive and negative influences on intracellular signaling. This review will detail recent findings regarding caveolin function in the brain.

Original languageEnglish (US)
Pages (from-to)3785-3795
Number of pages11
JournalCellular and Molecular Life Sciences
Volume67
Issue number22
DOIs
StatePublished - Nov 2010

Keywords

  • Caveolae
  • Caveolin
  • G-protein
  • Intracellular signaling
  • Membrane receptor
  • Neuron

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