Causes of kidney allograft loss in a large pediatric population at a single center

Blanche M. Chavers, Eun Mi Kim, Arthur J. Matas, Kristen J. Gillingham, John S. Najarian, S. Michael Mauer

Research output: Contribution to journalArticle

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Abstract

At our institution, 521 kidney transplants were performed in 429 children (mean age 8.7±5.6-years) between 1969 and 1991. Of these transplants, 408 were primary, 113 were retransplants, 347 were living related, 171 were cadaver, and 3 were living nonrelated. Immunosuppression consisted of prednisone, azathioprine, and Minnesota antilymphocyte globulin (non-CSA) in 339 patients, total lymphoid irradiation in 8, and, more recently, cyclosporine (CSA) in addition in 168 patients. Average followup was 8.8±6.0 years. Actuarial graft survival in the non-CSA versus CSA groups at 1 year was 77.0% versus 85.7%; at 5 years, 59.6% versus 71.9%. Of 136 non-CSA patients, causes of graft loss at 5 years included: chronic rejection in 55 (40.4%), acute rejection in 27 (19.9%), recurrent disease in 16 (11.8%), technical complications in 8 (5.9%), infectious complications in 4 (2.9%), other causes in 5 (3.7%), and death with a functioning graft in 21 (15.4%). Of 40 CSA patients, causes of graft loss at 5 years included: chronic rejection in 16 (40.0%), acute rejection in 8 (20.0%), recurrent disease in 6 (15.0%), technical complications in 3 (7.5%), other causes in 2 (5.0%), and death with a functioning graft in 5 (12.5%). The causes of graft loss did not significantly differ in the non-CSA and CSA groups. Chronic rejection was the most common cause of graft loss in both groups. Research focusing on chronic rejection is needed to improve graft outcome in pediatric kidney transplantation.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalPediatric Nephrology
Volume8
Issue number1
DOIs
StatePublished - Feb 1 1994

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Allografts
Pediatrics
Transplants
Kidney
Population
Lymphatic Irradiation
Antilymphocyte Serum
Azathioprine
Graft Survival
Prednisone
Cadaver
Kidney Transplantation
Immunosuppression
Cyclosporine
Research

Keywords

  • Allograft loss
  • Causes
  • Large single-center pediatric population

Cite this

Causes of kidney allograft loss in a large pediatric population at a single center. / Chavers, Blanche M.; Kim, Eun Mi; Matas, Arthur J.; Gillingham, Kristen J.; Najarian, John S.; Mauer, S. Michael.

In: Pediatric Nephrology, Vol. 8, No. 1, 01.02.1994, p. 57-61.

Research output: Contribution to journalArticle

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abstract = "At our institution, 521 kidney transplants were performed in 429 children (mean age 8.7±5.6-years) between 1969 and 1991. Of these transplants, 408 were primary, 113 were retransplants, 347 were living related, 171 were cadaver, and 3 were living nonrelated. Immunosuppression consisted of prednisone, azathioprine, and Minnesota antilymphocyte globulin (non-CSA) in 339 patients, total lymphoid irradiation in 8, and, more recently, cyclosporine (CSA) in addition in 168 patients. Average followup was 8.8±6.0 years. Actuarial graft survival in the non-CSA versus CSA groups at 1 year was 77.0{\%} versus 85.7{\%}; at 5 years, 59.6{\%} versus 71.9{\%}. Of 136 non-CSA patients, causes of graft loss at 5 years included: chronic rejection in 55 (40.4{\%}), acute rejection in 27 (19.9{\%}), recurrent disease in 16 (11.8{\%}), technical complications in 8 (5.9{\%}), infectious complications in 4 (2.9{\%}), other causes in 5 (3.7{\%}), and death with a functioning graft in 21 (15.4{\%}). Of 40 CSA patients, causes of graft loss at 5 years included: chronic rejection in 16 (40.0{\%}), acute rejection in 8 (20.0{\%}), recurrent disease in 6 (15.0{\%}), technical complications in 3 (7.5{\%}), other causes in 2 (5.0{\%}), and death with a functioning graft in 5 (12.5{\%}). The causes of graft loss did not significantly differ in the non-CSA and CSA groups. Chronic rejection was the most common cause of graft loss in both groups. Research focusing on chronic rejection is needed to improve graft outcome in pediatric kidney transplantation.",
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