Cause-specific mortality of dialysis patients after coronary revascularization: Why don't dialysis patients have better survival after coronary intervention?

Charles A. Herzog, Jeremy W. Strief, Allan J. Collins, David T. Gilbertson

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Introduction. The risk of death after coronary revascularization is markedly higher for dialysis patients than for the general population and the cause is inadequately explained. We analyzed cause-specific mortality of dialysis patients after coronary revascularization. Methods. This was a retrospective analysis of dialysis patients hospitalized for first surgical coronary revascularization after renal replacement therapy initiation from 1 January 1999 to 31 December 2002. Patients were identified from the US Renal Data System database (n = 1 516 251) by the International Classification of Diseases, Ninth Edition, Clinical Modification code for coronary artery bypass (CAB) surgery (36.1×). Endpoints were deaths due to all causes, all cardiac causes, cardiac arrest or arrhythmia, myocardial infarction, infection and other causes. Cause-specific mortality information was obtained from Centers for Medicare & Medicaid Services End-Stage Renal Disease Death Notification form (CMS 2746-U3). Results. For CAB patients (n = 5830), the all-cause mortality rate was 290 per 1000 patient-years and the rate for arrhythmically mediated deaths was 76 per 1000 patient-years. The largest cause of attributable mortality is cardiac arrest or arrhythmia, accounting for approximately one-fourth of all-cause mortality. Conclusions. The risk of arrhythmically mediated death may contribute to poor long-term outcomes after coronary revascularization in dialysis patients. A treatment strategy employing coronary revascularization and other interventions to reduce the sudden cardiac death risk might improve long-term survival.

Original languageEnglish (US)
Pages (from-to)2629-2633
Number of pages5
JournalNephrology Dialysis Transplantation
Volume23
Issue number8
DOIs
StatePublished - Aug 2008

Bibliographical note

Funding Information:
Acknowledgements. The authors thank Nan Booth, MSW, MPH, and Shane Nygaard, BA, of the USRDS Coordinating Center, for manuscript editing and preparation, respectively. The Cardiovascular Special Studies Center of the United States Renal Data System is supported by Contract No. HHSN267200715003C (National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland). This study was performed as a deliverable. The data reported here have been supplied by the United States Renal Data System (USRDS). The interpretation and reporting of these data are the responsibility of the authors and in no way should be seen as an official policy or interpretation of the US government.

Keywords

  • Coronary artery bypass surgery
  • Mortality
  • Renal dialysis

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