Causal inference and observational research: The utility of twins

Matt McGue, Merete Osler, Kaare Christensen

Research output: Contribution to journalReview articlepeer-review

257 Scopus citations


Valid causal inference is central to progress in theoretical and applied psychology. Although the randomized experiment is widely considered the gold standard for determining whether a given exposure increases the likelihood of some specified outcome, experiments are not always feasible and in some cases can result in biased estimates of causal effects. Alternatively, standard observational approaches are limited by the possibility of confounding, reverse causation, and the nonrandom distribution of exposure (i.e., selection). We describe the counterfactual model of causation and apply it to the challenges of causal inference in observational research, with a particular focus on aging. We argue that the study of twin pairs discordant on exposure, and in particular discordant monozygotic twins, provides a useful analog to the idealized counterfactual design. A review of discordant-twin studies in aging reveals that they are consistent with, but do not unambiguously establish, a causal effect of lifestyle factors on important late-life outcomes. Nonetheless, the existing studies are few in number and have clear limitations that have not always been considered in interpreting their results. It is concluded that twin researchers could make greater use of the discordant-twin design as one approach to strengthen causal inferences in observational research.

Original languageEnglish (US)
Pages (from-to)546-556
Number of pages11
JournalPerspectives on Psychological Science
Issue number5
StatePublished - Sep 2010

Bibliographical note

Funding Information:
This work was supported by grants from the U.S. National Institute on Aging (P01-AG08761), National Institute on Alcohol Abuse and Alcoholism (R01 AA009367), and the Danish National Research Foundation.


  • Causal inference
  • Discordant-twin design
  • Lifestyle influences in aging
  • Twin research

Fingerprint Dive into the research topics of 'Causal inference and observational research: The utility of twins'. Together they form a unique fingerprint.

Cite this