Causal evaluation of acute recurrent and chronic pancreatitis in children

Consensus from the INSPPIRE group

Cheryl E. Gariepy, Melvin B. Heyman, Mark E. Lowe, John F. Pohl, Steven L. Werlin, Michael Wilschanski, Bradley Barth, Douglas S. Fishman, Steven D. Freedman, Matthew J. Giefer, Tanja Gonska, Ryan Himes, Sohail Z. Husain, Veronique D. Morinville, Chee Y. Ooi, Sarah Jane Schwarzenberg, David M. Troendle, Elizabeth Yen, Aliye Uc

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives: Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) have been diagnosed in children at increasing rates during the past decade. As pediatric ARP and CP are still relatively rare conditions, little quality evidence is available on which to base the diagnosis and determination of etiology. The aim of the study was to review the current state of the literature regarding the etiology of these disorders and to developed a consensus among a panel of clinically active specialists caring for children with these disorders to help guide the diagnostic evaluation and identify areas most in need of future research. Methods: A systematic review of the literature was performed and scored for quality, followed by consensus statements developed and scored by each individual in the group for level of agreement and strength of the supporting data using a modified Delphi method. Scores were analyzed for the level of consensus achieved by the group. Results: The panel reached consensus on 27 statements covering the definitions of pediatric ARP and CP, evaluation for potential etiologies of these disorders, and long-term monitoring. Statements for which the group reached consensus to make no recommendation or could not reach consensus are discussed. Conclusions: This consensus helps define the minimal diagnostic evaluation and monitoring of children with ARP and CP. Even in areas in which we reached consensus, the quality of the evidence is weak, highlighting the need for further research. Improved understanding of the underlying cause will facilitate treatment development and targeting.

Original languageEnglish (US)
Pages (from-to)95-103
Number of pages9
JournalJournal of pediatric gastroenterology and nutrition
Volume64
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Chronic Pancreatitis
Consensus
Pancreatitis
Pediatrics
Research

Keywords

  • Autoimmune pancreatitis
  • CFTR
  • Hereditary pancreatitis
  • PRSS1
  • Pancreatic insufficiency

Cite this

Causal evaluation of acute recurrent and chronic pancreatitis in children : Consensus from the INSPPIRE group. / Gariepy, Cheryl E.; Heyman, Melvin B.; Lowe, Mark E.; Pohl, John F.; Werlin, Steven L.; Wilschanski, Michael; Barth, Bradley; Fishman, Douglas S.; Freedman, Steven D.; Giefer, Matthew J.; Gonska, Tanja; Himes, Ryan; Husain, Sohail Z.; Morinville, Veronique D.; Ooi, Chee Y.; Schwarzenberg, Sarah Jane; Troendle, David M.; Yen, Elizabeth; Uc, Aliye.

In: Journal of pediatric gastroenterology and nutrition, Vol. 64, No. 1, 01.01.2017, p. 95-103.

Research output: Contribution to journalArticle

Gariepy, CE, Heyman, MB, Lowe, ME, Pohl, JF, Werlin, SL, Wilschanski, M, Barth, B, Fishman, DS, Freedman, SD, Giefer, MJ, Gonska, T, Himes, R, Husain, SZ, Morinville, VD, Ooi, CY, Schwarzenberg, SJ, Troendle, DM, Yen, E & Uc, A 2017, 'Causal evaluation of acute recurrent and chronic pancreatitis in children: Consensus from the INSPPIRE group', Journal of pediatric gastroenterology and nutrition, vol. 64, no. 1, pp. 95-103. https://doi.org/10.1097/MPG.0000000000001446
Gariepy, Cheryl E. ; Heyman, Melvin B. ; Lowe, Mark E. ; Pohl, John F. ; Werlin, Steven L. ; Wilschanski, Michael ; Barth, Bradley ; Fishman, Douglas S. ; Freedman, Steven D. ; Giefer, Matthew J. ; Gonska, Tanja ; Himes, Ryan ; Husain, Sohail Z. ; Morinville, Veronique D. ; Ooi, Chee Y. ; Schwarzenberg, Sarah Jane ; Troendle, David M. ; Yen, Elizabeth ; Uc, Aliye. / Causal evaluation of acute recurrent and chronic pancreatitis in children : Consensus from the INSPPIRE group. In: Journal of pediatric gastroenterology and nutrition. 2017 ; Vol. 64, No. 1. pp. 95-103.
@article{8a733de5196247988bc132278166b82c,
title = "Causal evaluation of acute recurrent and chronic pancreatitis in children: Consensus from the INSPPIRE group",
abstract = "Objectives: Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) have been diagnosed in children at increasing rates during the past decade. As pediatric ARP and CP are still relatively rare conditions, little quality evidence is available on which to base the diagnosis and determination of etiology. The aim of the study was to review the current state of the literature regarding the etiology of these disorders and to developed a consensus among a panel of clinically active specialists caring for children with these disorders to help guide the diagnostic evaluation and identify areas most in need of future research. Methods: A systematic review of the literature was performed and scored for quality, followed by consensus statements developed and scored by each individual in the group for level of agreement and strength of the supporting data using a modified Delphi method. Scores were analyzed for the level of consensus achieved by the group. Results: The panel reached consensus on 27 statements covering the definitions of pediatric ARP and CP, evaluation for potential etiologies of these disorders, and long-term monitoring. Statements for which the group reached consensus to make no recommendation or could not reach consensus are discussed. Conclusions: This consensus helps define the minimal diagnostic evaluation and monitoring of children with ARP and CP. Even in areas in which we reached consensus, the quality of the evidence is weak, highlighting the need for further research. Improved understanding of the underlying cause will facilitate treatment development and targeting.",
keywords = "Autoimmune pancreatitis, CFTR, Hereditary pancreatitis, PRSS1, Pancreatic insufficiency",
author = "Gariepy, {Cheryl E.} and Heyman, {Melvin B.} and Lowe, {Mark E.} and Pohl, {John F.} and Werlin, {Steven L.} and Michael Wilschanski and Bradley Barth and Fishman, {Douglas S.} and Freedman, {Steven D.} and Giefer, {Matthew J.} and Tanja Gonska and Ryan Himes and Husain, {Sohail Z.} and Morinville, {Veronique D.} and Ooi, {Chee Y.} and Schwarzenberg, {Sarah Jane} and Troendle, {David M.} and Elizabeth Yen and Aliye Uc",
year = "2017",
month = "1",
day = "1",
doi = "10.1097/MPG.0000000000001446",
language = "English (US)",
volume = "64",
pages = "95--103",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Causal evaluation of acute recurrent and chronic pancreatitis in children

T2 - Consensus from the INSPPIRE group

AU - Gariepy, Cheryl E.

AU - Heyman, Melvin B.

AU - Lowe, Mark E.

AU - Pohl, John F.

AU - Werlin, Steven L.

AU - Wilschanski, Michael

AU - Barth, Bradley

AU - Fishman, Douglas S.

AU - Freedman, Steven D.

AU - Giefer, Matthew J.

AU - Gonska, Tanja

AU - Himes, Ryan

AU - Husain, Sohail Z.

AU - Morinville, Veronique D.

AU - Ooi, Chee Y.

AU - Schwarzenberg, Sarah Jane

AU - Troendle, David M.

AU - Yen, Elizabeth

AU - Uc, Aliye

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objectives: Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) have been diagnosed in children at increasing rates during the past decade. As pediatric ARP and CP are still relatively rare conditions, little quality evidence is available on which to base the diagnosis and determination of etiology. The aim of the study was to review the current state of the literature regarding the etiology of these disorders and to developed a consensus among a panel of clinically active specialists caring for children with these disorders to help guide the diagnostic evaluation and identify areas most in need of future research. Methods: A systematic review of the literature was performed and scored for quality, followed by consensus statements developed and scored by each individual in the group for level of agreement and strength of the supporting data using a modified Delphi method. Scores were analyzed for the level of consensus achieved by the group. Results: The panel reached consensus on 27 statements covering the definitions of pediatric ARP and CP, evaluation for potential etiologies of these disorders, and long-term monitoring. Statements for which the group reached consensus to make no recommendation or could not reach consensus are discussed. Conclusions: This consensus helps define the minimal diagnostic evaluation and monitoring of children with ARP and CP. Even in areas in which we reached consensus, the quality of the evidence is weak, highlighting the need for further research. Improved understanding of the underlying cause will facilitate treatment development and targeting.

AB - Objectives: Acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) have been diagnosed in children at increasing rates during the past decade. As pediatric ARP and CP are still relatively rare conditions, little quality evidence is available on which to base the diagnosis and determination of etiology. The aim of the study was to review the current state of the literature regarding the etiology of these disorders and to developed a consensus among a panel of clinically active specialists caring for children with these disorders to help guide the diagnostic evaluation and identify areas most in need of future research. Methods: A systematic review of the literature was performed and scored for quality, followed by consensus statements developed and scored by each individual in the group for level of agreement and strength of the supporting data using a modified Delphi method. Scores were analyzed for the level of consensus achieved by the group. Results: The panel reached consensus on 27 statements covering the definitions of pediatric ARP and CP, evaluation for potential etiologies of these disorders, and long-term monitoring. Statements for which the group reached consensus to make no recommendation or could not reach consensus are discussed. Conclusions: This consensus helps define the minimal diagnostic evaluation and monitoring of children with ARP and CP. Even in areas in which we reached consensus, the quality of the evidence is weak, highlighting the need for further research. Improved understanding of the underlying cause will facilitate treatment development and targeting.

KW - Autoimmune pancreatitis

KW - CFTR

KW - Hereditary pancreatitis

KW - PRSS1

KW - Pancreatic insufficiency

UR - http://www.scopus.com/inward/record.url?scp=84992401844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992401844&partnerID=8YFLogxK

U2 - 10.1097/MPG.0000000000001446

DO - 10.1097/MPG.0000000000001446

M3 - Article

VL - 64

SP - 95

EP - 103

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

IS - 1

ER -