Catecholamine effects on dissociated tiger salamander Muller (glial) cells

Diane S. Henshel, Robert F. Miller

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell response to the CAs is concentration dependent. At high concentrations ascorbate, an antioxidant used to protect the CAs from oxidation, stimulated a net outward current and a decrease in Rn. When the effects of ascorbate were considered, the CA response at 1 mM was no larger than the response at 100 μM, indicating that 100 μM CA maximally stimulated the Muller cell response.

Original languageEnglish (US)
Pages (from-to)208-214
Number of pages7
JournalBrain Research
Volume575
Issue number2
DOIs
StatePublished - Mar 20 1992

Keywords

  • Catecholamine
  • Dopamine
  • Epinephrine
  • Glia
  • Muller cell
  • Retina
  • Salamander
  • Whole-cell recording

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