Catechol estrogen adducts

Yusuf J. Abul-Hajj; Paul L. Cisek

doi:10.1016/0022-4731(88)90212-9

Catechol estrogen adducts

Yusuf J. Abul-Hajj
, Paul L. Cisek

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Reaction of estrone-3,4-o-quinone with ethanethiol and glutathione leads to the formation of 4-hydroxyestrone-2-thioethers. Incubations of [1-³H]hydroxyestrone with rat liver microsomes and NADPH in the presence of glutathione results in the formation of 4-hydroxyestrone-S-glutathione with no release of tritium in the water indicating GSH addition to C-2 of 4-hydroxyestrone.

Original language	English (US)
Pages (from-to)	107-110
Number of pages	4
Journal	Journal of Steroid Biochemistry
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/0022-4731(88)90212-9
State	Published - Jul 1988

Bibliographical note

Funding Information:
Acknowledgement-This work was supported by NIH grant

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10.1016/0022-4731(88)90212-9

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title = "Catechol estrogen adducts",

abstract = "Reaction of estrone-3,4-o-quinone with ethanethiol and glutathione leads to the formation of 4-hydroxyestrone-2-thioethers. Incubations of [1-3H]hydroxyestrone with rat liver microsomes and NADPH in the presence of glutathione results in the formation of 4-hydroxyestrone-S-glutathione with no release of tritium in the water indicating GSH addition to C-2 of 4-hydroxyestrone.",

author = "Abul-Hajj, \{Yusuf J.\} and Cisek, \{Paul L.\}",

note = "Funding Information: Acknowledgement-This work was supported by NIH grant",

year = "1988",

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doi = "10.1016/0022-4731(88)90212-9",

language = "English (US)",

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AU - Abul-Hajj, Yusuf J.

AU - Cisek, Paul L.

N1 - Funding Information: Acknowledgement-This work was supported by NIH grant

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Y1 - 1988/7

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AB - Reaction of estrone-3,4-o-quinone with ethanethiol and glutathione leads to the formation of 4-hydroxyestrone-2-thioethers. Incubations of [1-3H]hydroxyestrone with rat liver microsomes and NADPH in the presence of glutathione results in the formation of 4-hydroxyestrone-S-glutathione with no release of tritium in the water indicating GSH addition to C-2 of 4-hydroxyestrone.

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Catechol estrogen adducts

Abstract

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