Abstract
Reaction of estrone-3,4-o-quinone with ethanethiol and glutathione leads to the formation of 4-hydroxyestrone-2-thioethers. Incubations of [1-3H]hydroxyestrone with rat liver microsomes and NADPH in the presence of glutathione results in the formation of 4-hydroxyestrone-S-glutathione with no release of tritium in the water indicating GSH addition to C-2 of 4-hydroxyestrone.
Original language | English (US) |
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Pages (from-to) | 107-110 |
Number of pages | 4 |
Journal | Journal of Steroid Biochemistry |
Volume | 31 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1988 |
Bibliographical note
Funding Information:Acknowledgement-This work was supported by NIH grant