Catechol estrogen adducts

Yusuf J. Abul-Hajj, Paul L. Cisek

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Reaction of estrone-3,4-o-quinone with ethanethiol and glutathione leads to the formation of 4-hydroxyestrone-2-thioethers. Incubations of [1-3H]hydroxyestrone with rat liver microsomes and NADPH in the presence of glutathione results in the formation of 4-hydroxyestrone-S-glutathione with no release of tritium in the water indicating GSH addition to C-2 of 4-hydroxyestrone.

Original languageEnglish (US)
Pages (from-to)107-110
Number of pages4
JournalJournal of Steroid Biochemistry
Volume31
Issue number1
DOIs
StatePublished - Jul 1988

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