Catch-up growth, metabolic, and cardiovascular risk in post-institutionalized Romanian adolescents

Alva Tang, Natalie Slopen, Charles A. Nelson, Charles H. Zeanah, Michael K Georgieff, Nathan A. Fox

Research output: Contribution to journalArticle

Abstract

Background: Reduced prenatal growth followed by rapid postnatal weight gain are risk factors for developing metabolic and cardiovascular disease. Children reared in institutions experience a similar pattern of growth restriction followed by catch-up growth after removal. We explored whether patterns of catch-up growth affect metabolic and cardiovascular outcomes in previously institutionalized adolescents. Method: A longitudinal study of institutionalized infants randomized to care as usual (n = 68) or foster care intervention (n = 68), and never institutionalized controls (n = 127). Body mass index (BMI) was measured at baseline (20 months), 30, 42 months, and ages 8, 12, 16. At age 16, metabolic and pro-inflammatory markers were derived from blood samples. Results: Four BMI trajectories were derived (i.e., average-stable, low-stable, elevated, and accelerated). The accelerated trajectory was comprised predominately of children randomized to foster care, who also exhibited higher levels of glycosylated hemoglobin and C-reactive protein than the other three trajectories. Also, children placed in foster care at younger ages were more likely to be on the accelerated rather than the average-stable trajectory. Conclusions: Although catch-up growth is viewed as a positive improvement among post-institutionalized children, rapid/continuous increases in body size pose a health concern. Attention should be given to monitoring weight gain, diet, and physical activity.

Original languageEnglish (US)
Pages (from-to)842-848
Number of pages7
JournalPediatric Research
Volume84
Issue number6
DOIs
StatePublished - Dec 1 2018

Fingerprint

Institutionalized Adolescent
Growth
Weight Gain
Body Mass Index
Institutionalized Child
Metabolic Diseases
Body Size
C-Reactive Protein
Longitudinal Studies
Cardiovascular Diseases
Exercise
Diet
Health

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

Cite this

Catch-up growth, metabolic, and cardiovascular risk in post-institutionalized Romanian adolescents. / Tang, Alva; Slopen, Natalie; Nelson, Charles A.; Zeanah, Charles H.; Georgieff, Michael K; Fox, Nathan A.

In: Pediatric Research, Vol. 84, No. 6, 01.12.2018, p. 842-848.

Research output: Contribution to journalArticle

Tang, Alva ; Slopen, Natalie ; Nelson, Charles A. ; Zeanah, Charles H. ; Georgieff, Michael K ; Fox, Nathan A. / Catch-up growth, metabolic, and cardiovascular risk in post-institutionalized Romanian adolescents. In: Pediatric Research. 2018 ; Vol. 84, No. 6. pp. 842-848.
@article{a88e3d3d8a3b4142b0ebccd65471e303,
title = "Catch-up growth, metabolic, and cardiovascular risk in post-institutionalized Romanian adolescents",
abstract = "Background: Reduced prenatal growth followed by rapid postnatal weight gain are risk factors for developing metabolic and cardiovascular disease. Children reared in institutions experience a similar pattern of growth restriction followed by catch-up growth after removal. We explored whether patterns of catch-up growth affect metabolic and cardiovascular outcomes in previously institutionalized adolescents. Method: A longitudinal study of institutionalized infants randomized to care as usual (n = 68) or foster care intervention (n = 68), and never institutionalized controls (n = 127). Body mass index (BMI) was measured at baseline (20 months), 30, 42 months, and ages 8, 12, 16. At age 16, metabolic and pro-inflammatory markers were derived from blood samples. Results: Four BMI trajectories were derived (i.e., average-stable, low-stable, elevated, and accelerated). The accelerated trajectory was comprised predominately of children randomized to foster care, who also exhibited higher levels of glycosylated hemoglobin and C-reactive protein than the other three trajectories. Also, children placed in foster care at younger ages were more likely to be on the accelerated rather than the average-stable trajectory. Conclusions: Although catch-up growth is viewed as a positive improvement among post-institutionalized children, rapid/continuous increases in body size pose a health concern. Attention should be given to monitoring weight gain, diet, and physical activity.",
author = "Alva Tang and Natalie Slopen and Nelson, {Charles A.} and Zeanah, {Charles H.} and Georgieff, {Michael K} and Fox, {Nathan A.}",
year = "2018",
month = "12",
day = "1",
doi = "10.1038/s41390-018-0196-4",
language = "English (US)",
volume = "84",
pages = "842--848",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Catch-up growth, metabolic, and cardiovascular risk in post-institutionalized Romanian adolescents

AU - Tang, Alva

AU - Slopen, Natalie

AU - Nelson, Charles A.

AU - Zeanah, Charles H.

AU - Georgieff, Michael K

AU - Fox, Nathan A.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Background: Reduced prenatal growth followed by rapid postnatal weight gain are risk factors for developing metabolic and cardiovascular disease. Children reared in institutions experience a similar pattern of growth restriction followed by catch-up growth after removal. We explored whether patterns of catch-up growth affect metabolic and cardiovascular outcomes in previously institutionalized adolescents. Method: A longitudinal study of institutionalized infants randomized to care as usual (n = 68) or foster care intervention (n = 68), and never institutionalized controls (n = 127). Body mass index (BMI) was measured at baseline (20 months), 30, 42 months, and ages 8, 12, 16. At age 16, metabolic and pro-inflammatory markers were derived from blood samples. Results: Four BMI trajectories were derived (i.e., average-stable, low-stable, elevated, and accelerated). The accelerated trajectory was comprised predominately of children randomized to foster care, who also exhibited higher levels of glycosylated hemoglobin and C-reactive protein than the other three trajectories. Also, children placed in foster care at younger ages were more likely to be on the accelerated rather than the average-stable trajectory. Conclusions: Although catch-up growth is viewed as a positive improvement among post-institutionalized children, rapid/continuous increases in body size pose a health concern. Attention should be given to monitoring weight gain, diet, and physical activity.

AB - Background: Reduced prenatal growth followed by rapid postnatal weight gain are risk factors for developing metabolic and cardiovascular disease. Children reared in institutions experience a similar pattern of growth restriction followed by catch-up growth after removal. We explored whether patterns of catch-up growth affect metabolic and cardiovascular outcomes in previously institutionalized adolescents. Method: A longitudinal study of institutionalized infants randomized to care as usual (n = 68) or foster care intervention (n = 68), and never institutionalized controls (n = 127). Body mass index (BMI) was measured at baseline (20 months), 30, 42 months, and ages 8, 12, 16. At age 16, metabolic and pro-inflammatory markers were derived from blood samples. Results: Four BMI trajectories were derived (i.e., average-stable, low-stable, elevated, and accelerated). The accelerated trajectory was comprised predominately of children randomized to foster care, who also exhibited higher levels of glycosylated hemoglobin and C-reactive protein than the other three trajectories. Also, children placed in foster care at younger ages were more likely to be on the accelerated rather than the average-stable trajectory. Conclusions: Although catch-up growth is viewed as a positive improvement among post-institutionalized children, rapid/continuous increases in body size pose a health concern. Attention should be given to monitoring weight gain, diet, and physical activity.

UR - http://www.scopus.com/inward/record.url?scp=85055111020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055111020&partnerID=8YFLogxK

U2 - 10.1038/s41390-018-0196-4

DO - 10.1038/s41390-018-0196-4

M3 - Article

VL - 84

SP - 842

EP - 848

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 6

ER -