Catalytic Mechanism of NADP⁺-Dependent Isocitrate Dehydrogenase: Implications from the Structures of Magnesium-Isocitrate and NADP⁺ Complexes

Keyphrases

• Magnesium 100%
• Isocitrate Dehydrogenase 1 (IDH1) 100%
• NADP+ 100%
• Isocitrate 100%
• Catalytic Mechanism 100%
• Escherichia Coli 33%
• Aspartate 33%
• Lactate Dehydrogenase 33%
• Dehydrogenation 33%
• Hydroxyl 33%
• Nucleotide-binding Protein 33%
• Carboxylate 16%
• Metal Ions 16%
• Binding Site 16%
• Side Chain 16%
• Water Molecule 16%
• Active Sites 16%
• Stereospecificity 16%
• Coenzyme Binding 16%
• Negative Charge 16%
• Hydrides 16%
• Decarboxylation 16%
• α-ketoglutarate (α-KG) 16%
• Ternary Complex 16%
• Nucleotide-binding Domain 16%
• Supersecondary Structure 16%
• Large Domain 16%

Biochemistry, Genetics and Molecular Biology

• Catalytic Mechanism 100%
• Isocitrate Dehydrogenase 100%
• Nicotinamide Adenine Dinucleotide Phosphate 100%
• Binding Protein 33%
• Escherichia coli 33%
• Dehydrogenation 33%
• Lactate Dehydrogenase 33%
• Aspartic Acid 33%
• Active Site 16%
• Coenzyme 16%
• Binding Domain 16%
• Ternary Complex 16%
• Stereospecificity 16%
• Binding Site 16%
• Decarboxylation 16%
• Supersecondary Structure 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Isocitric Acid 100%
• Nicotinamide Adenine Dinucleotide Phosphate 100%
• Isocitrate Dehydrogenase 100%
• Escherichia coli 33%
• Nucleotide Binding Protein 33%
• Aspartic Acid 33%
• Lactate Dehydrogenase 33%
• Carboxylate 16%
• Binding Site 16%
• Dimer 16%
• Magnesium Derivative 16%
• Base 16%
• Metal Ion 16%