Catalytic Hydrogenolysis of Aryl C-F Bonds Using a Bimetallic Rhodium-Indium Complex

James T. Moore, Connie C. Lu

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

A homogeneous rhodium-indium catalyst hydrodefluorinates substrates bearing strong aryl C-F bonds, including difluoro- and fluorobenzene, using 1 atm of H2, alkoxide bases, and moderate temperatures (70-90 °C). Characterization of catalytic intermediates establishes a formal Rh-I/RhI redox cycle. The Rh → In interaction is proposed to enable catalysis by stabilizing the reactive Rh-I species, which is responsible for cleaving the Ar-F bond and is ultimately regenerated using H2 and base.

Original languageEnglish (US)
Pages (from-to)11641-11646
Number of pages6
JournalJournal of the American Chemical Society
Volume142
Issue number27
DOIs
StatePublished - Jul 8 2020

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© 2020 American Chemical Society.

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