TY - JOUR
T1 - Catalytic carbon-carbon σ bond activation
T2 - An intramolecular carbo-acylation reaction with acylquinolines
AU - Dreis, Ashley M.
AU - Douglas, Christopher J
PY - 2009/1/21
Y1 - 2009/1/21
N2 - Carbon-carbon sigma-bond activation is a contemporary challenge for organometallic chemistry and catalysis. Herein, we disclose a new alkene carboacylation reaction initiated by quinoline-directed, rhodium-catalyzed C-C bond activation. The alkene carboacylation allows for the construction of all-carbon quaternary centers, with a broad substrate scope, providing access to carbocyclic and heterocyclic ring systems in good to excellent yields.
AB - Carbon-carbon sigma-bond activation is a contemporary challenge for organometallic chemistry and catalysis. Herein, we disclose a new alkene carboacylation reaction initiated by quinoline-directed, rhodium-catalyzed C-C bond activation. The alkene carboacylation allows for the construction of all-carbon quaternary centers, with a broad substrate scope, providing access to carbocyclic and heterocyclic ring systems in good to excellent yields.
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U2 - 10.1021/ja8066308
DO - 10.1021/ja8066308
M3 - Article
C2 - 19105696
AN - SCOPUS:67749099638
SN - 0002-7863
VL - 131
SP - 412
EP - 413
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 2
ER -