Silyl-inspired spirocycle: The title reaction is the first example of a catalytic asymmetric [3+2] annulation reaction with allylsilanes. The annulation reaction utilizes a chiral ScCl 2(SbF 6)/L catalyst and TMSCl as a promoter to afford spirooxindoles in excellent enantioselectivity at room temperature. The Si-C bond can be oxidized to deliver hydroxy-substituted spirooxindoles. TMS=trimethylsilyl.
- allylic compounds
- asymmetric catalysis