Cataloging SCN resistance loci in North American public soybean breeding programs

Anser Mahmood, Kristin D. Bilyeu, Mária Škrabišová, Jana Biová, Elizabeth J. De Meyer, Clinton G. Meinhardt, Mariola Usovsky, Qijian Song, Aaron J. Lorenz, Melissa G. Mitchum, Grover Shannon, Andrew M. Scaboo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Soybean cyst nematode (SCN) is a destructive pathogen of soybeans responsible for annual yield loss exceeding $1.5 billion in the United States. Here, we conducted a series of genome-wide association studies (GWASs) to understand the genetic landscape of SCN resistance in the University of Missouri soybean breeding programs (Missouri panel), as well as germplasm and cultivars within the United States Department of Agriculture (USDA) Uniform Soybean Tests—Northern Region (NUST). For the Missouri panel, we evaluated the resistance of breeding lines to SCN populations HG 2.5.7 (Race 1), HG (Race 2), HG 0 (Race 3), HG 2.5.7 (Race 5), and HG (Race 14) and identified seven quantitative trait nucleotides (QTNs) associated with SCN resistance on chromosomes 2, 8, 11, 14, 17, and 18. Additionally, we evaluated breeding lines in the NUST panel for resistance to SCN populations HG 2.5.7 (Race 1) and HG 0 (Race 3), and we found three SCN resistance-associated QTNs on chromosomes 7 and 18. Through these analyses, we were able to decipher the impact of seven major genetic loci, including three novel loci, on resistance to several SCN populations and identified candidate genes within each locus. Further, we identified favorable allelic combinations for resistance to individual SCN HG types and provided a list of available germplasm for integration of these unique alleles into soybean breeding programs. Overall, this study offers valuable insight into the landscape of SCN resistance loci in U.S. public soybean breeding programs and provides a framework to develop new and improved soybean cultivars with diverse plant genetic modes of SCN resistance.

Original languageEnglish (US)
Article number1270546
JournalFrontiers in Plant Science
StatePublished - 2023

Bibliographical note

Publisher Copyright:
Copyright © 2023 Mahmood, Bilyeu, Škrabišová, Biová, De Meyer, Meinhardt, Usovsky, Song, Lorenz, Mitchum, Shannon and Scaboo.


  • genome wide association study (GWAS)
  • resistance to Heterodera glycines 1 (Rhg1)
  • SCN (Heterodera glycines Ichinohe)
  • soybean (Glycine max (L.) Merr.)
  • α-soluble N-ethylmaleimide sensitive factor attachment protein (α-SNAP)

PubMed: MeSH publication types

  • Journal Article


Dive into the research topics of 'Cataloging SCN resistance loci in North American public soybean breeding programs'. Together they form a unique fingerprint.

Cite this