Castration increases [125I]MK801 binding in the hippocampus of male rats

Laura Kus, Robert J. Handa, Joan M. Hautman, Alvin J. Beitz

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This study examines the effect of castration and androgen replacement on [125I]MK801 binding in the hippocampus. In castrated male rats, [125I]MK801 binding was significantly increased in both the stratum oriens and radiatum and the pyramidal cell layer of CA1. In contrast, no increase in [125I]MK801 binding was observed in the stratum oriens and radiatum of CA1 of castrated rats that were treated with dihydrotestosterone. No change in [125I]MK801 binding was observed in the CA3 region or dentate gyrus after castration. The observed increase in [125I]MK801 binding in pyramidal cell neurons within CA1 suggests that androgens may potentially affect hippocampal function by modulating pyramidal cell NMDA receptors.

Original languageEnglish (US)
Pages (from-to)270-274
Number of pages5
JournalBrain Research
Issue number2
StatePublished - Jun 19 1995

Bibliographical note

Funding Information:
This work was supported by NIH grants DA06682 and NS 31318 to A.J.B. and NSF-BNS9109226 to R.J.H. We thank Jennifer J. Sanderson for her excellent technical assistance.


  • Androgen
  • Autoradiography
  • CA1
  • Castration
  • Hippocampus
  • MK801
  • N-Methyl-d-aspartate
  • Testosterone


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