Caspases, apoptosis and aging

Jian Hua Zhang, Yingpei Zhang, Brain Herman

Research output: Contribution to journalReview articlepeer-review

107 Scopus citations


Caspases are a group of cysteine dependent aspartate-specific proteases. Originally found as the homolog of Ced-3 in C. elegans, 14 caspases have now been identified in mammals to date. Caspases play important roles in both the intrinsic and extrinsic apoptotic pathways and interact with the non-caspase apoptotic pathways. A number of recent published observations have suggested a strong association between apoptosis, age-related diseases and aging. Findings from our group and others reveal a strong correlation between alterations in caspase activity and aging. In this view point, we summarize current knowledge of the connection between caspases and aging observed in a variety of model systems from cultured cells in vitro to the in vivo models of rodents and humans.

Original languageEnglish (US)
Pages (from-to)357-366
Number of pages10
JournalAgeing Research Reviews
Issue number4
StatePublished - Oct 2003


  • Aging
  • Apoptosis
  • Caspase


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