Caspase 9 is essential for herpes simplex virus type 2-induced apoptosis in T cells

Michael J Vanden Oever, Jin Young Han

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Herpes simplex virus type 2 (HSV-2) induces apoptosis in T cells by a caspase-dependent mechanism. Apoptosis can occur via extrinsic (death receptor) and/or intrinsic (mitochondrial) pathways. Here, we show that the initiator caspase for the intrinsic pathway is activated in T cells following HSV-2 exposure. To determine the respective contributions of intrinsic and extrinsic pathways, we assessed apoptosis in Jurkat cells that are deficient in caspase 8 or Fas-associating protein with death domain (FADD) for the extrinsic pathway and in cells deficient in caspase 9 for the intrinsic pathway. Our results indicate HSV-2-induced apoptosis in T cells occurs via the intrinsic pathway.

Original languageEnglish (US)
Pages (from-to)3116-3120
Number of pages5
JournalJournal of virology
Volume84
Issue number6
DOIs
StatePublished - Mar 2010

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