Case studies in the management of refractory bleeding in patients with haemophilia A and inhibitors

L. A. Valentino; G. Allen; J. C. Gill; A. Hurlet; B. A. Konkle; C. A. Leissinger; L. Luchtman-Jones; J. Powell; M. Reding; K. Stine

doi:10.1111/hae.12095

Case studies in the management of refractory bleeding in patients with haemophilia A and inhibitors

L. A. Valentino, G. Allen, J. C. Gill, A. Hurlet, B. A. Konkle, C. A. Leissinger, L. Luchtman-Jones, J. Powell, M. Reding, K. Stine

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7 Scopus citations

Abstract

In haemophilia patients with well-established high-titer inhibitors, even seemingly minor acute bleeding episodes or surgical procedures may become refractory to treatment and transform into limb- or life-threatening situations. In the absence of evidence-based treatment guidelines, this article presents 10 cases of difficult to control acute and surgical bleeding and offers consensus opinions regarding their management from a panel of experienced haemophilia treaters.

Original language	English (US)
Pages (from-to)	e151-e166
Journal	Haemophilia
Volume	19
Issue number	3
DOIs	https://doi.org/10.1111/hae.12095
State	Published - May 2013

Keywords

Adjuvant therapy
Bypassing therapy
Haemophilia A
Inhibitors
Refractory bleeding

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10.1111/hae.12095

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abstract = "In haemophilia patients with well-established high-titer inhibitors, even seemingly minor acute bleeding episodes or surgical procedures may become refractory to treatment and transform into limb- or life-threatening situations. In the absence of evidence-based treatment guidelines, this article presents 10 cases of difficult to control acute and surgical bleeding and offers consensus opinions regarding their management from a panel of experienced haemophilia treaters.",

keywords = "Adjuvant therapy, Bypassing therapy, Haemophilia A, Inhibitors, Refractory bleeding",

author = "Valentino, {L. A.} and G. Allen and Gill, {J. C.} and A. Hurlet and Konkle, {B. A.} and Leissinger, {C. A.} and L. Luchtman-Jones and J. Powell and M. Reding and K. Stine",

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AU - Valentino, L. A.

AU - Allen, G.

AU - Gill, J. C.

AU - Hurlet, A.

AU - Konkle, B. A.

AU - Leissinger, C. A.

AU - Luchtman-Jones, L.

AU - Powell, J.

AU - Reding, M.

AU - Stine, K.

PY - 2013/5

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N2 - In haemophilia patients with well-established high-titer inhibitors, even seemingly minor acute bleeding episodes or surgical procedures may become refractory to treatment and transform into limb- or life-threatening situations. In the absence of evidence-based treatment guidelines, this article presents 10 cases of difficult to control acute and surgical bleeding and offers consensus opinions regarding their management from a panel of experienced haemophilia treaters.

AB - In haemophilia patients with well-established high-titer inhibitors, even seemingly minor acute bleeding episodes or surgical procedures may become refractory to treatment and transform into limb- or life-threatening situations. In the absence of evidence-based treatment guidelines, this article presents 10 cases of difficult to control acute and surgical bleeding and offers consensus opinions regarding their management from a panel of experienced haemophilia treaters.

KW - Adjuvant therapy

KW - Bypassing therapy

KW - Haemophilia A

KW - Inhibitors

KW - Refractory bleeding

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Case studies in the management of refractory bleeding in patients with haemophilia A and inhibitors

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Keywords

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