Many dementia subtypes have more shared signs and symptoms than defining ones. We review 8 cases with 4 overlapping syndromes and demonstrate how to distinguish the cases. These include focal cortical presentations of Alzheimer's disease (AD; posterior cortical atrophy and corticobasal syndrome [CBS]), fluent aphasia (semantic dementia and logopenic aphasia), late-onset slowly progressive dementia (hippocampal sclerosis and limbic predominant AD) and rapidly progressive dementia (Creutzfeldt–Jakob disease and limbic encephalitis). Recognizing the different syndromes can help the clinician to improve their diagnostic skills, leading to improved patient outcomes by early and accurate diagnosis, prompt treatment, and appropriate counseling and guidance.
Bibliographical noteFunding Information:
Disclosures: Dr. Murray is partly supported by Donors Cure Foundation New Vision Award and Gerstner Family Career Development Award. The study is supported in part by Mayo Clinic Alzheimer's Disease Research Center (ADRC) grant P50AG 16574-14 (PI: Ronald Petersen, MD, PhD). The authors have nothing to disclose.
© 2016 Elsevier Inc.
- Atypical Alzheimer's
- Fluent aphasia
- Late-onset dementia
- Rapid dementia