Case series exploring hormonal sensitivity in prostate cancer patients harboring the germline African-ancestry HOXB13 X285K variant

Mayuko Kanayama; Emeline Colomba; Yusra Shao; Sarah M. Nielsen; Edward D. Esplin; Changxue Lu; William B. Isaacs; John C. Henegan; Elisabeth I. Heath; Jun Luo; Régine Marlin; Emmanuel S. Antonarakis

doi:10.1038/s41391-025-00994-5

Case series exploring hormonal sensitivity in prostate cancer patients harboring the germline African-ancestry HOXB13 X285K variant

Mayuko Kanayama, Emeline Colomba, Yusra Shao, Sarah M. Nielsen, Edward D. Esplin, Changxue Lu, William B. Isaacs, John C. Henegan, Elisabeth I. Heath, Jun Luo, Régine Marlin, Emmanuel S. Antonarakis

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Recently, a germline HOXB13 variant, X285K was identified as a risk factor for prostate cancer in men of African ancestry. While this variant is likely associated with more aggressive prostate cancer, there has not yet been an in-depth clinical description of individual patients carrying this variant and their response to systemic therapies. Methods: We studied six cases of germline X285K carriers with metastatic hormone-sensitive prostate cancer to characterize their hormonal sensitivity or resistance. Conclusions: Longitudinal outcome analysis indicates that patients carrying X285K generally show favorable responses to therapies targeting the androgen receptor (AR), a finding that requires confirmation.

Original language	English (US)
Journal	Prostate Cancer and Prostatic Diseases
DOIs	https://doi.org/10.1038/s41391-025-00994-5
State	Accepted/In press - 2025

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Publisher Copyright:
© The Author(s), under exclusive licence to Springer Nature Limited 2025.

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10.1038/s41391-025-00994-5

Cite this

Kanayama, M., Colomba, E., Shao, Y., Nielsen, S. M., Esplin, E. D., Lu, C., Isaacs, W. B., Henegan, J. C., Heath, E. I., Luo, J., Marlin, R., & Antonarakis, E. S. (Accepted/In press). Case series exploring hormonal sensitivity in prostate cancer patients harboring the germline African-ancestry HOXB13 X285K variant. Prostate Cancer and Prostatic Diseases. https://doi.org/10.1038/s41391-025-00994-5

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title = "Case series exploring hormonal sensitivity in prostate cancer patients harboring the germline African-ancestry HOXB13 X285K variant",

abstract = "Background: Recently, a germline HOXB13 variant, X285K was identified as a risk factor for prostate cancer in men of African ancestry. While this variant is likely associated with more aggressive prostate cancer, there has not yet been an in-depth clinical description of individual patients carrying this variant and their response to systemic therapies. Methods: We studied six cases of germline X285K carriers with metastatic hormone-sensitive prostate cancer to characterize their hormonal sensitivity or resistance. Conclusions: Longitudinal outcome analysis indicates that patients carrying X285K generally show favorable responses to therapies targeting the androgen receptor (AR), a finding that requires confirmation.",

author = "Mayuko Kanayama and Emeline Colomba and Yusra Shao and Nielsen, \{Sarah M.\} and Esplin, \{Edward D.\} and Changxue Lu and Isaacs, \{William B.\} and Henegan, \{John C.\} and Heath, \{Elisabeth I.\} and Jun Luo and R{\'e}gine Marlin and Antonarakis, \{Emmanuel S.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Nature Limited 2025.",

year = "2025",

doi = "10.1038/s41391-025-00994-5",

language = "English (US)",

journal = "Prostate Cancer and Prostatic Diseases",

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T1 - Case series exploring hormonal sensitivity in prostate cancer patients harboring the germline African-ancestry HOXB13 X285K variant

AU - Kanayama, Mayuko

AU - Colomba, Emeline

AU - Shao, Yusra

AU - Nielsen, Sarah M.

AU - Esplin, Edward D.

AU - Lu, Changxue

AU - Isaacs, William B.

AU - Henegan, John C.

AU - Heath, Elisabeth I.

AU - Luo, Jun

AU - Marlin, Régine

AU - Antonarakis, Emmanuel S.

PY - 2025

Y1 - 2025

N2 - Background: Recently, a germline HOXB13 variant, X285K was identified as a risk factor for prostate cancer in men of African ancestry. While this variant is likely associated with more aggressive prostate cancer, there has not yet been an in-depth clinical description of individual patients carrying this variant and their response to systemic therapies. Methods: We studied six cases of germline X285K carriers with metastatic hormone-sensitive prostate cancer to characterize their hormonal sensitivity or resistance. Conclusions: Longitudinal outcome analysis indicates that patients carrying X285K generally show favorable responses to therapies targeting the androgen receptor (AR), a finding that requires confirmation.

AB - Background: Recently, a germline HOXB13 variant, X285K was identified as a risk factor for prostate cancer in men of African ancestry. While this variant is likely associated with more aggressive prostate cancer, there has not yet been an in-depth clinical description of individual patients carrying this variant and their response to systemic therapies. Methods: We studied six cases of germline X285K carriers with metastatic hormone-sensitive prostate cancer to characterize their hormonal sensitivity or resistance. Conclusions: Longitudinal outcome analysis indicates that patients carrying X285K generally show favorable responses to therapies targeting the androgen receptor (AR), a finding that requires confirmation.

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Case series exploring hormonal sensitivity in prostate cancer patients harboring the germline African-ancestry HOXB13 X285K variant

Abstract

Bibliographical note

PubMed: MeSH publication types

UN SDGs

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