Case report on hereditary non-polyposis colon cancer (HNPCC) in Nigeria.

C. A. Adebamowo; O. Adeyi; R. Pyatt; T. W. Prior; R. B. Chadwick; A. de la Chapelle

Case report on hereditary non-polyposis colon cancer (HNPCC) in Nigeria.

C. A. Adebamowo, O. Adeyi, R. Pyatt, T. W. Prior, R. B. Chadwick, A. de la Chapelle

Research output: Contribution to journal › Article › peer-review

Abstract

The role of genetic factors in the etiology of colorectal cancers (CRCs) has recently been elucidated with the discovery of the mismatch repair. These genes are responsible for less than 5% of all cases of CRCs in Caucasian series. In this pilot study, tumors from 5 randomly ascertained CRC patients were subjected to microsatellite analysis, and two were microsatellite unstable. Both of these two patients had germline mutations in MSH2. If this finding can be confirmed in a larger series of patients, it suggests that MMR genes play an important role in the etiology of CRCs in Africa.

Original language	English (US)
Pages (from-to)	71-73
Number of pages	3
Journal	African Journal of Medicine and Medical Sciences
Volume	29
Issue number	1
State	Published - Mar 2000
Externally published	Yes

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title = "Case report on hereditary non-polyposis colon cancer (HNPCC) in Nigeria.",

abstract = "The role of genetic factors in the etiology of colorectal cancers (CRCs) has recently been elucidated with the discovery of the mismatch repair. These genes are responsible for less than 5% of all cases of CRCs in Caucasian series. In this pilot study, tumors from 5 randomly ascertained CRC patients were subjected to microsatellite analysis, and two were microsatellite unstable. Both of these two patients had germline mutations in MSH2. If this finding can be confirmed in a larger series of patients, it suggests that MMR genes play an important role in the etiology of CRCs in Africa.",

author = "Adebamowo, {C. A.} and O. Adeyi and R. Pyatt and Prior, {T. W.} and Chadwick, {R. B.} and {de la Chapelle}, A.",

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AU - Adeyi, O.

AU - Pyatt, R.

AU - Prior, T. W.

AU - Chadwick, R. B.

AU - de la Chapelle, A.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 2000/3

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N2 - The role of genetic factors in the etiology of colorectal cancers (CRCs) has recently been elucidated with the discovery of the mismatch repair. These genes are responsible for less than 5% of all cases of CRCs in Caucasian series. In this pilot study, tumors from 5 randomly ascertained CRC patients were subjected to microsatellite analysis, and two were microsatellite unstable. Both of these two patients had germline mutations in MSH2. If this finding can be confirmed in a larger series of patients, it suggests that MMR genes play an important role in the etiology of CRCs in Africa.

AB - The role of genetic factors in the etiology of colorectal cancers (CRCs) has recently been elucidated with the discovery of the mismatch repair. These genes are responsible for less than 5% of all cases of CRCs in Caucasian series. In this pilot study, tumors from 5 randomly ascertained CRC patients were subjected to microsatellite analysis, and two were microsatellite unstable. Both of these two patients had germline mutations in MSH2. If this finding can be confirmed in a larger series of patients, it suggests that MMR genes play an important role in the etiology of CRCs in Africa.

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Case report on hereditary non-polyposis colon cancer (HNPCC) in Nigeria.

Abstract

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