Case report: Guillain-barré syndrome associated with zika virus infection in a traveler returning from Guyana

Ryan G. Fabrizius, Kathryn Anderson, Brett Hendel-Paterson, Robyn M. Kaiser, Salahudin Maalim, Patricia F. Walker

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Zika virus (ZIKV) is a mosquito-borne flavivirus with a significant public health impact highlighted by the ongoing epidemic in the Americas. We describe a 44-year-old male presenting to our tropical medicine center with complaints of fever, headache, joint pain, and rash after recent travel to Guyana. The patient subsequently developed gait imbalance and lower extremity weakness with clinical examination, cerebrospinal fluid studies, and magnetic resonance imaging of the spine consistent with a diagnosis of Guillain-Barré syndrome (GBS). ZIKV infection was confirmed via detection of ZIKV RNA in urine by polymerase chain reaction. The patient was treated with intravenous immunoglobulin and experienced near-complete neurologic recovery, reporting ongoing mild paresthesia up to 2 months later. This case highlights the diagnostic challenges posed by ZIKV and underscores the need for clinician awareness of the potential for neurological complications such as GBS with ZIKV infection.

Original languageEnglish (US)
Pages (from-to)1161-1165
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume95
Issue number5
DOIs
StatePublished - Nov 2016

Bibliographical note

Publisher Copyright:
© 2016 by The American Society of Tropical Medicine and Hygiene.

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